Taylor M J, Voros J G, Logan W J, Malone M A
Division of Neurology, Hospital for Sick Children, University of Toronto, Ontario, Canada.
Biol Psychol. 1993 Sep;36(3):139-56. doi: 10.1016/0301-0511(93)90015-z.
Thirty-two children with attention deficit hyperactivity disorder (ADHD) undergoing a 4 week double-blind medication assessment (methylphenidate) and 32 normal controls were studied using event-related potentials (ERPs). The ERPs were recorded from 13 active electrodes during a visual feature detection task. Significant age effects were found in N2, P3a and P3b latencies, that did not interact with group. The P3a and P3b latencies were significantly longer in the ADHD children on baseline testing; there were no latency differences between the groups of children when the normal controls were compared with the ADHD children on their optimal drug dosage (as determined by extensive behavioural and cognitive assessments). There were no significant distributional effects either between groups, or with the ADHD children as a function of medication; there were also no significant differences in reaction time measures. Thus, only the ERPs reflected slowed processing in the ADHD children that normalized on appropriate medication.
对32名患有注意力缺陷多动障碍（ADHD）且正在接受为期4周的双盲药物评估（哌甲酯）的儿童以及32名正常对照儿童，使用事件相关电位（ERP）进行了研究。在视觉特征检测任务期间，从13个有效电极记录ERP。在N2、P3a和P3b潜伏期发现了显著的年龄效应，且该效应不与组别相互作用。在基线测试时，ADHD儿童的P3a和P3b潜伏期显著更长；当将正常对照儿童与服用最佳药物剂量（通过广泛的行为和认知评估确定）的ADHD儿童进行比较时，两组儿童之间的潜伏期没有差异。无论是组间还是ADHD儿童内部，作为药物作用的函数，均未发现显著的分布效应；反应时间测量也没有显著差异。因此，只有ERP反映出ADHD儿童的加工速度减慢，而在使用适当药物后恢复正常。
