Kiss J, Patel A J, Halász B
Department of Neuroendocrinology, Hungarian Academy of Sciences, Budapest.
Neuroreport. 1993 Sep 30;4(12):1315-8. doi: 10.1097/00001756-199309150-00007.
Low-affinity nerve growth factor receptor (p75NGFR) and vasoactive intestinal polypeptide (VIP) immunoreactive neuronal structures and their interrelationship were investigated at light and electron microscopic levels in rat suprachiasmatic nucleus (SCN). p75NGFR immunoreactive neuronal perikarya were detected in the ventrolateral part, while the dorsolateral region contained mainly receptor positive fibres. Double-label immunocytochemistry showed that nearly all p75NGFR positive neurones in the ventrolateral region of the SCN also contained VIP. The axons of the receptor positive neurones terminated on unidentified neurones. In single-label experiments, the axons of the VIP containing neurones formed axodendritic synapses on cells containing the same peptide. The findings provide further insight on the chemical structural organization of the SCN.
在大鼠视交叉上核（SCN）中，利用光镜和电镜技术研究了低亲和力神经生长因子受体（p75NGFR）和血管活性肠肽（VIP）免疫反应性神经元结构及其相互关系。在腹外侧部分检测到p75NGFR免疫反应性神经元胞体，而背外侧区域主要包含受体阳性纤维。双标免疫细胞化学显示，SCN腹外侧区域几乎所有p75NGFR阳性神经元也含有VIP。受体阳性神经元的轴突终止于未识别的神经元上。在单标实验中，含VIP神经元的轴突在含有相同肽的细胞上形成轴-树突触。这些发现为SCN的化学结构组织提供了进一步的见解。
