Girolami A, Fabris F, Marco L, Peruffo R
Acta Haematol. 1976;56(3):151-9. doi: 10.1159/000207932.
Platelet aggregation in citrated and heparinized plasma by ionophore A 23187 and Ristocetin was studied in normal subjects and in patients with von Willebrand's disease and congenital afibrinogenemia. Aggregation by ionophore was normal in all groups both in citrated and heparinized plasma. Aggregation by Ristocetin in citrated plasma was normal in congenital afibrinogenemia, in normal subjects and in types II and III of von Willebrand's disease. It was absent in classical von Willebrand's disease, type I. In heparinized plasma it was absent in all groups, except in some patients with von Willebrand's disease, type III. It is concluded that ionophore A 23187 behaves in a different way than Ristocetin and has no diagnostic implications.
在正常受试者以及患有血管性血友病和先天性无纤维蛋白原血症的患者中，研究了离子载体A 23187和瑞斯托菌素在枸橼酸盐血浆和肝素化血浆中的血小板聚集情况。在枸橼酸盐血浆和肝素化血浆中，所有组中离子载体诱导的聚集均正常。在先天性无纤维蛋白原血症、正常受试者以及血管性血友病II型和III型中，瑞斯托菌素在枸橼酸盐血浆中诱导的聚集正常。在经典的血管性血友病I型中，该聚集不存在。在肝素化血浆中，除了一些血管性血友病III型患者外，所有组中该聚集均不存在。结论是，离子载体A 23187的行为方式与瑞斯托菌素不同，且无诊断意义。
