Olson J D, Brockway W J, Fass D N, Magnuson M A, Bowie E J
Am J Clin Pathol. 1975 Feb;63(2):210-8. doi: 10.1093/ajcp/63.2.210.
Normal subjects, patients with various bleeding disorders, and patients with von Willebrand's disease were studied. All patients with von Willebrand's disease had decreased levels of ristocetin-Willebrand factor (range, 0 to 41%) as compared with all other subjects (range, 79 to 202%). Ristocetin-induced platelet aggregation of platelet-rich plasma was abnormal in all patients with von Willebrand's disease tested, and it was possible to correct this abnormal response by addition of normal platelet-poor plasma. Abnormal ristocetin-induced platelet aggregation was seen in patients with intrinsic platelet disorders or, on some occasions, in normal patients who had ingested aspirin. Ristocetin-induced platelet aggregation is not diagnostic, but it may be useful as a simple screening test for patients with possible von Willebrand's disease. In conjunction with other tests, the assay for ristocetin-Willebrand factor will be useful in diagnosis and evaluation of these patients.
对正常受试者、患有各种出血性疾病的患者以及患有血管性血友病的患者进行了研究。与所有其他受试者（范围为79%至202%）相比，所有血管性血友病患者的瑞斯托霉素-血管性血友病因子水平均降低（范围为0至41%）。在所有接受测试的血管性血友病患者中，富含血小板血浆的瑞斯托霉素诱导的血小板聚集均异常，并且通过添加正常的乏血小板血浆有可能纠正这种异常反应。在患有血小板内在疾病的患者中，或者在某些情况下，在摄入阿司匹林的正常患者中，可见瑞斯托霉素诱导的血小板聚集异常。瑞斯托霉素诱导的血小板聚集不具有诊断性，但它可能作为对可能患有血管性血友病的患者的一种简单筛查试验有用。与其他测试相结合，瑞斯托霉素-血管性血友病因子检测将有助于这些患者的诊断和评估。
