Girolami A, De Marco L, Virgolini L, Peruffo R, Fabris F
Blut. 1975 Oct;31(4):219-26. doi: 10.1007/BF01633505.
Platelet aggregation by various inductors was studied in citrated and heparinized plasma of the following groups of subjects: Normal, hemophilia A, combined factor V and factor VIII deficiency, v. Willeprand's disease and congenital afibrinognemia. The results may be summarized as follows: A-platelet aggregation in citrated plasm 1) platelet aggregation by common inductors ADP, adrenalin and collagen was normal in all groups of subjects but for the patients with congential afibrinogenemia in whom adrenalin induced aggregation was absent or markedly refuced whereas ADP and collagen gave slightly reduced or near normal aggregation curves. 2) platelet aggregation by ristocetin was normal in all groups of subjects but for v. Willebrand's disease in which it was absent. B-platelet aggregation in heparized plasma. 1) platelet aggregation by common inductors resulted to be normal in all groups of subjects except in congenital afibrinogenemia. In this latter case the pattern was still mildly defective but here was an increased aggregation as compared to citrated plasma. These findings have been interpretemmon inductors. 2) platelet aggregation by ristocetin resulted to be absent in all groups of subjects investigated. The possible mechanism of action of the inhibitory effect exercised py heparin with regard to restocetin is discussed.
在以下几组受试者的枸橼酸化和肝素化血浆中，研究了各种诱导剂引起的血小板聚集情况：正常组、甲型血友病组、联合因子V和因子VIII缺乏组、血管性血友病组以及先天性无纤维蛋白原血症组。结果可总结如下：A - 枸橼酸化血浆中的血小板聚集：1）除先天性无纤维蛋白原血症患者外，所有受试者组中由常见诱导剂ADP、肾上腺素和胶原引起的血小板聚集均正常。在先天性无纤维蛋白原血症患者中，肾上腺素诱导的聚集不存在或明显减弱，而ADP和胶原诱导的聚集曲线略有降低或接近正常。2）除血管性血友病组外，所有受试者组中由瑞斯托菌素引起的血小板聚集均正常，在血管性血友病组中该聚集不存在。B - 肝素化血浆中的血小板聚集：1）除先天性无纤维蛋白原血症外，所有受试者组中由常见诱导剂引起的血小板聚集均正常。在先天性无纤维蛋白原血症这种情况下，模式仍有轻度缺陷，但与枸橼酸化血浆相比聚集增加。这些发现已被解释……常见诱导剂。2）在所研究的所有受试者组中，由瑞斯托菌素引起的血小板聚集均不存在。讨论了肝素对瑞斯托菌素产生抑制作用的可能作用机制。
