Cova L, Duflot A, Prave M, Trepo C
INSERM U271, Lyon, France.
Arch Virol Suppl. 1993;8:81-7. doi: 10.1007/978-3-7091-9312-9_9.
The association between chronic infection by hepadnaviruses isolated from human (HBV), woodchuck (WHV), ground squirrel (GSHV) and development of hepatocellular carcinoma (HCC) in their respective hosts is well established (reviewed in [11, 15, 17]). By contrast, the association of duck hepatitis B virus (DHBV) infection with HCC is less documented. Pekin ducks congenitally infected with DHBV and followed for several years throughout the world do not develop liver tumors: HCC has been found only in domestic ducks from a single area of China, Qidong. Several factors such as DHBV carrier rate, breed and age of ducks, subtype of DHBV and environmental carcinogens are suspected to contribute to this striking difference between the geographical repartition of liver cancer in DHBV-carrier ducks. In this brief review we will consider successively the role of these different factors in duck liver oncogenesis.
从人类分离出的嗜肝DNA病毒（乙肝病毒，HBV）、土拨鼠（土拨鼠肝炎病毒，WHV）、地松鼠（地松鼠肝炎病毒，GSHV）的慢性感染与其各自宿主肝细胞癌（HCC）发生之间的关联已得到充分证实（见[11, 15, 17]中的综述）。相比之下，鸭乙型肝炎病毒（DHBV）感染与HCC之间的关联记录较少。在世界各地对先天性感染DHBV的北京鸭进行数年跟踪观察，发现它们不会发生肝肿瘤：仅在中国启东的一个地区的家鸭中发现了HCC。怀疑诸如DHBV携带率、鸭的品种和年龄、DHBV亚型以及环境致癌物等多种因素导致了DHBV携带鸭肝癌地理分布的这种显著差异。在这篇简短的综述中，我们将依次探讨这些不同因素在鸭肝肿瘤发生中的作用。
