Santavirta S, Konttinen Y T, Nordström D, Gristina A
Orthopaedic Hospital of the Invalid Foundation, Helsinki, Finland.
Eur J Med. 1993 Mar;2(3):170-2.
The biocompatibility of total hip replacement prostheses and methylmethacrylate cement which is used for fixation of the prosthetic components has been subject to debate for three decades.
We have studied the host response to total hip replacement prostheses in a number of clinical and experimental investigations.
Methylmethacrylate cement is immunologically relatively inert while it causes, in in vitro experiments and in vivo, a foreign body type of reaction. In cementless prostheses, the wear of polyethylene which is used for lining of the acetabular component causes a similar foreign body type of reaction.
Ultimately, the total hip prosthesis cannot be made invisible to the host system. The host response can be controlled and reduced, but not eliminated by technical improvement and development of more biocompatible materials.
全髋关节置换假体以及用于固定假体部件的甲基丙烯酸甲酯骨水泥的生物相容性已历经三十年的争论。
我们在多项临床和实验研究中研究了宿主对全髋关节置换假体的反应。
甲基丙烯酸甲酯骨水泥在免疫方面相对惰性，但在体外实验和体内会引发异物型反应。在无骨水泥假体中，用于髋臼部件内衬的聚乙烯磨损会引发类似的异物型反应。
最终，全髋关节假体无法做到对宿主系统隐形。宿主反应可以通过技术改进和开发更具生物相容性的材料来控制和降低，但无法消除。
