Hatakeyama S, Suzuki A
J Oral Pathol. 1978 Oct;7(5):295-300. doi: 10.1111/j.1600-0714.1978.tb01813.x.
Two cases of adenomatoid odontogenic tumor were examined by light and electron microscopy. Morphologically the tumors could be divided into four layers. The ultrastructure of the tumor cells of each layer was revealed to be similar respectively to that of four layers seen in the enamel organ of a normal tooth germ. Duct-like structures and eosinophilic small areas were frequently present in compactly proliferating cell layers. Short columnar cells forming duct-like structures and eosinophilic small areas appeared similar ultrastructurally to ameloblasts during predentin formation. Therefore it seems reasonable to assume that this tumor originates from the enamel organ. The contents in the lumen of each eosinophilic small area varied, and seemed to be secreted into the stroma by circumscribing epithelial tumor cells. A fine filamentous layer was present in both of the duct-like structures and some of the eosinophilic small areas, and the former was different from the latter with respect to the alcian blue (pH 2.5) and toluidine blue (pH 4.4) staining reactions.
对两例腺样牙源性肿瘤进行了光镜和电镜检查。从形态学上看，肿瘤可分为四层。结果显示，每层肿瘤细胞的超微结构分别与正常牙胚釉器中所见的四层相似。在紧密增殖的细胞层中经常出现导管样结构和嗜酸性小区域。形成导管样结构和嗜酸性小区域的短柱状细胞在超微结构上与前期牙本质形成过程中的成釉细胞相似。因此，推测该肿瘤起源于釉器似乎是合理的。每个嗜酸性小区域管腔内的内容物各不相同，似乎是由包绕的上皮性肿瘤细胞分泌到基质中的。在导管样结构和一些嗜酸性小区域中均存在一层细丝状物质，前者在阿尔辛蓝（pH 2.5）和甲苯胺蓝（pH 4.4）染色反应方面与后者不同。
