Philipsen H P, Reichart P A
Oral Biology Unit, Prince Philip Dental Hospital, University of Hong Kong, Hong Kong.
J Oral Pathol Med. 1996 Oct;25(9):491-6. doi: 10.1111/j.1600-0714.1996.tb00303.x.
The ultrastructure of tumour cells and tumour droplets (TD, non-calcified amorphous masses) was studied in three cases of AOT using freshly prepared tissue. The fine structure of the epithelial tumour cells (cell type I-III) corresponded to that of earlier descriptions. The extracellular location of TD was clearly demonstrated. TD were of varying, sometimes bizarre, configuration. Some TD showed a homogeneous matrix; however, in addition most revealed electron-dense plaques. At high magnification, homogeneous types of TD showed only tubular elements; all others revealed granulo-tubular structures. The tubular elements were arranged concentrically. The nature of the TD is discussed and compared to former interpretations. From the present ultrastructural findings, it appears that the TD most probably represent some form of enamel matrix and as such may be considered a type of pre-enamel. Further studies are needed to elucidate the complex structure of the TD-material so characteristic of the AOT.
在三例腺样牙源性肿瘤（AOT）中，使用新鲜制备的组织研究了肿瘤细胞和肿瘤小滴（TD，非钙化无定形团块）的超微结构。上皮性肿瘤细胞（I - III型细胞）的精细结构与早期描述一致。TD的细胞外位置得到了清晰显示。TD的形态各异，有时很奇特。一些TD显示出均匀的基质；然而，除此之外，大多数还显示出电子致密斑块。在高倍镜下，均匀类型的TD仅显示管状结构；其他所有TD都显示出颗粒 - 管状结构。管状结构呈同心排列。对TD的性质进行了讨论，并与以前的解释进行了比较。从目前的超微结构研究结果来看，TD很可能代表某种形式的釉质基质，因此可以被认为是一种前期釉质。需要进一步研究以阐明AOT特有的TD物质的复杂结构。
