Wollheim F A, Telhag H, Henricsson A, Geborek P
Department of Rheumatology, Lund University Hospital, Sweden.
Clin Immunol Immunopathol. 1994 Jan;70(1):19-21. doi: 10.1006/clin.1994.1004.
In rheumatoid arthritis (RA) erosive joint changes are the dominating cause of chronic disability. In a cohort of patients with RA followed from early stages of the disease, we have observed a much larger prevalence of destructions in hips than in knee joints. The latter were frequently injected with triamcinolone hexacetonide in contrast to the former. In order to elucidate a possible role of local glucocorticoids we studied the antigen-induced arthritis model of Dumonde and Glynn in rabbits which, untreated, caused advanced joint destruction in 3/5 animals, whereas 0/14 animals receiving 3 injections of triamcinolone hexacetonide developed no such changes. The treatment was effective when started up to 2 weeks after induction of the arthritis. It is suggested that locally administered glucocorticoids may prevent or delay large joint destruction in RA.
在类风湿关节炎（RA）中，侵蚀性关节改变是导致慢性残疾的主要原因。在一组从疾病早期开始随访的RA患者队列中，我们观察到髋关节破坏的发生率远高于膝关节。与髋关节相比，膝关节经常注射己曲安奈德。为了阐明局部糖皮质激素可能发挥的作用，我们研究了Dumonde和Glynn在兔子身上建立的抗原诱导性关节炎模型，未经治疗的情况下，3/5的动物会出现晚期关节破坏，而接受3次己曲安奈德注射的14只动物中没有出现这种变化。在关节炎诱导后2周内开始治疗是有效的。这表明局部应用糖皮质激素可能预防或延缓RA中大型关节的破坏。
