Truss M C, Djamilian M H, Tan H K, Hinrichs H, Feistner H, Stief C G, Jonas U
Department of Urology, Hannover Medical School, FRG.
Eur Urol. 1993;24(3):358-65.
Since the recent introduction of cavernous electromyography by Gerstenberg and Wagner, a new too for the study of erectile dysfunction in man is available. The refinement of this method, single potential analysis of cavernous electrical activity (SPACE), offers a straightforward approach to the diagnosis of cavernous autonomic neuropathy and smooth muscle myopathy by minimal invasive means. SPACE was done in more than 500 consecutive patients with erectile dysfunction and in 85 normal control subjects. With increasing experience the methodology was refined with respect to the used hardware as well as cut-off frequencies. In normal control subjects, SPACE showed a reproducible regular activity with potentials of low frequency and electrical silence inbetween. The potentials were synchronous throughout the cavernous bodies. In patients with peripheral autonomic denervation, asynchronous potentials with higher frequencies and irregular shape were found. Normal and abnormal potentials were found in patients with upper spinal cord lesions. Recordings obtained with surface electrodes showed similar characteristics when compared with recordings obtained with needle electrodes. Recent studies show that SPACE provides independent information about the autonomic and myogenic intactness of the cavernous tissue. Currently, a computerized expert system and a graded classification for easier interpretation is being developed with first results. We conclude that cavernous electrical activity can be recorded. SPACE is a reproducible diagnostic tool for erectile dysfunction.
自从格施滕贝格和瓦格纳最近引入海绵体肌电图以来，一种用于研究男性勃起功能障碍的新工具问世了。这种方法的改进，即海绵体电活动单电位分析（SPACE），通过微创手段为海绵体自主神经病变和平滑肌肌病的诊断提供了一种直接的方法。SPACE应用于500多名连续的勃起功能障碍患者以及85名正常对照受试者。随着经验的增加，在使用的硬件以及截止频率方面对该方法进行了改进。在正常对照受试者中，SPACE显示出可重复的规则活动，电位频率较低，其间有电静息期。电位在整个海绵体内是同步的。在周围自主神经去神经支配的患者中，发现了频率较高且形状不规则的异步电位。在上脊髓病变的患者中发现了正常和异常电位。与针电极记录相比，表面电极记录显示出相似的特征。最近的研究表明，SPACE提供了有关海绵体组织自主神经和肌源性完整性的独立信息。目前，正在开发一个计算机化专家系统和一个分级分类以便于解释，并已取得初步结果。我们得出结论，海绵体电活动是可以记录的。SPACE是一种用于勃起功能障碍的可重复的诊断工具。
