Proos L A
Department of Pediatrics, Uppsala University Children's Hospital, Sweden.
Horm Res. 1993;39 Suppl 3:18-24. doi: 10.1159/000182781.
A secular trend towards higher final height and earlier pubertal maturation is seen in countries with favourable socio-economic development and higher social classes in countries are also associated with taller height and earlier maturation. Environmental factors, such as nutrition and infections, appear to be the main causes for differences in growth and maturation between ethnic and social groups. Differences in final height are mainly due to prepubertal growth. Studies on immigrant children and children adopted into privileged conditions from developing countries confirm the influence of early growth on subsequent growth. Catch-up growth in adopted children could only partially compensate for early stunting, and in several cases was cut short by early pubertal development. A minority developed very early puberty and eventually very short final height. The optimal rate of catch-up growth, the trigger mechanism for early puberty, and the effect of various types of nutritional intervention need to be studied. The studies reported here indicate the critical importance of optimal intra-uterine, infant and childhood growth as a basis for satisfactory growth during adolescence.
在社会经济发展良好的国家,可观察到一种朝着更高最终身高和更早青春期成熟发展的长期趋势,而且在这些国家中,较高社会阶层也与更高的身高和更早的成熟相关联。环境因素,如营养和感染,似乎是不同种族和社会群体在生长和成熟方面存在差异的主要原因。最终身高的差异主要归因于青春期前的生长。对移民儿童以及从发展中国家收养到优越环境中的儿童的研究证实了早期生长对后续生长的影响。被收养儿童的追赶生长只能部分弥补早期发育迟缓,而且在某些情况下会因青春期过早发育而中断。少数儿童青春期发育极早,最终身高非常矮。需要研究追赶生长的最佳速率、青春期早熟的触发机制以及各种营养干预措施的效果。此处报告的研究表明,最佳的宫内、婴儿期和儿童期生长对于青春期实现满意的生长至关重要。