两种品系大鼠的血浆激素水平与致癌物诱导的乳腺肿瘤发生率
Plasma hormone levels and the incidence of carcinogen-induced mammary tumours in two strains of rat.
作者信息
Hawkins R A, Drewitt D, Freedman B, Killin E, Jenner D A, Cameron E H
出版信息
Br J Cancer. 1976 Nov;34(5):546-9. doi: 10.1038/bjc.1976.209.
The incidence of mammary tumours developing after administration of the carcinogen DMBA (at 50 days of age) has been determined in 2 strains of Sprague-Dawley rat. Untreated animals of each strain were exsanguinated in dioestrus at a time corresponding to the early post-carcinogen stage (at 70 days of age) and the plasma concentrations of prolactin, oestradiol-17B and progesterone were measured by radioimmunoassay. In an inbred strain of rats, tumour-induction rate was 6-4% and plasma prolactin concentration was 2-5 x lower than that found in a random-bred strain with a tumour-induction rate of 41-6%. No difference was found between the 2 strains in the level of either ovarian hormone. It is concluded that the difference between these strains in mammary gland susceptibility to DMBA may be related to plasma prolactin concentration, but it is unlikely to be determined by the ovarian hormones.
已测定了2个品系的斯普拉格-道利大鼠在给予致癌物二甲基苯并蒽（50日龄时）后乳腺肿瘤的发生率。在与致癌物注射后早期阶段相对应的时间（70日龄），将每个品系未处理的动物在动情间期放血，并通过放射免疫测定法测量催乳素、雌二醇-17β和孕酮的血浆浓度。在一个近交系大鼠中，肿瘤诱导率为6-4%，血浆催乳素浓度比肿瘤诱导率为41-6%的随机繁殖品系低2-5倍。在两种卵巢激素水平上，这两个品系之间未发现差异。结论是，这些品系在乳腺对二甲基苯并蒽的易感性方面的差异可能与血浆催乳素浓度有关，但不太可能由卵巢激素决定。
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