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可植入装置中聚合物降解的机制。2. 聚（DL-乳酸）

Mechanisms of polymer degradation in implantable devices. 2. Poly(DL-lactic acid).

作者信息

Ali S A, Doherty P J, Williams D F

机构信息

Department of Clinical Engineering, Royal Liverpool University Hospital, United Kingdom.

出版信息

J Biomed Mater Res. 1993 Nov;27(11):1409-18. doi: 10.1002/jbm.820271108.

DOI:10.1002/jbm.820271108
PMID:8263003
Abstract

The hydrolytic degradation of poly(DL-lactic acid) in an aqueous environment in which hydroxyl radicals have been generated has been investigated. Different methods (gel permeation chromatography, differential scanning calorimetry, and scanning electron microscopy) were employed to study the mechanisms of degradation of this amorphous physiologically absorbable polymer. The data indicated that the hydroxyl radical is likely to be a significant factor in the degradation of this polymer.

摘要

研究了聚（DL-乳酸）在已产生羟基自由基的水性环境中的水解降解。采用了不同方法（凝胶渗透色谱法、差示扫描量热法和扫描电子显微镜）来研究这种无定形生理可吸收聚合物的降解机制。数据表明，羟基自由基很可能是该聚合物降解的一个重要因素。

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