Feeney S, Goodall E, Silverstone T
Academic Unit of Human Psychopharmacology, Medical College of St. Bartholomew's Hospital, London, UK.
Int Clin Psychopharmacol. 1993 Fall;8(3):139-42. doi: 10.1097/00004850-199300830-00001.
Twelve normal weight healthy male volunteers participated in a double-blind, placebo-controlled trial of the effects of d- and l-fenfluramine, d-amphetamine, and the interactions between the two isomers of fenfluramine with amphetamine, on cortisol secretion. d-Fenfluramine and d-amphetamine in combination produced the greatest cortisolaemic effect, suggesting that they act by differing neurochemical pathways. d-Fenfluramine produced a significant effect, but l-fenfluramine produced little effect, suggesting that the cortisol-releasing properties of racemic fenfluramine reside in the d-isomer.
12名体重正常的健康男性志愿者参与了一项双盲、安慰剂对照试验，该试验旨在研究右旋和左旋芬氟拉明、右旋苯丙胺以及芬氟拉明两种异构体与苯丙胺之间的相互作用对皮质醇分泌的影响。右旋芬氟拉明和右旋苯丙胺联合使用产生了最大的皮质醇血症效应，这表明它们通过不同的神经化学途径发挥作用。右旋芬氟拉明产生了显著效应，但左旋芬氟拉明几乎没有效果，这表明消旋芬氟拉明的皮质醇释放特性存在于右旋异构体中。
