Kharazmi A, Haghighi P, Haghshenas M, Nasr K, Abadi P, Rezai H R
Clin Exp Immunol. 1976 Oct;26(1):124-8.
Twenty-seven intestinal lymphoma patients were studied. Abnormal alpha-chain immunoglobulin was detected in the sera of seven of these patients. The alpha-chain disease patients were from the rural areas of Southern Iran. They were of low socio-economic status and their age ranged from 15-44 years. Predominant clinical features were malabsorption, diarrhoea , abdominal pain, vomiting, and weight loss. Infiltration of mucosa of the small intestine with plasma cells and also distortion and flattening of the villi were common histopathologic characteristics of these patients. Involvement of mesenteric lymph nodes with infiltration of tumour cells was observed in a number of cases. Protein studies revealed no significant differences between the serum immunoglobulin levels of these patients and normal values. Immunoelectrophoresis using monospecific antiserum against H-chain of human IgA demonstrated the abnormal precipitin band of alpha-chain disease protein.
对27例肠道淋巴瘤患者进行了研究。在其中7例患者的血清中检测到异常α链免疫球蛋白。α链病患者来自伊朗南部农村地区。他们社会经济地位较低，年龄在15至44岁之间。主要临床特征为吸收不良、腹泻、腹痛、呕吐和体重减轻。小肠黏膜被浆细胞浸润以及绒毛扭曲和变平是这些患者常见的组织病理学特征。在一些病例中观察到肠系膜淋巴结受累并有肿瘤细胞浸润。蛋白质研究显示这些患者的血清免疫球蛋白水平与正常值之间无显著差异。使用针对人IgA重链的单特异性抗血清进行免疫电泳，显示出α链病蛋白的异常沉淀带。
