Gross G J, Warltier D C, Hardman H F
Eur J Pharmacol. 1976 Mar;36(1):267-71. doi: 10.1016/0014-2999(76)90285-5.
The effect of propranolol on the oxyhemoglobin dissociation curve (P-50) of coronary venous blood was studied in isolated canine hearts. I.v. administration of propranolol (0.5, 5.0 mg/kg) produced no significant change in P-50 over 4 hr. Following propranolol, an intracoronary infusion of nitroglycerin (10 mug/min) increased P-50. Addition of propranolol (5 X 10(-5) M to 1 X 10(-4)M) to central venous blood in vitro produced a significant increase in P-50. These data indicate that propranolol increases P-50 in vitro but does not increase P-50 in vivo, whereas nitroglycerin increases P-50 In vivo but not in vitro.
在离体犬心脏中研究了普萘洛尔对冠状静脉血氧合血红蛋白解离曲线（P-50）的影响。静脉注射普萘洛尔（0.5、5.0毫克/千克）在4小时内未使P-50发生显著变化。给予普萘洛尔后，冠状动脉内输注硝酸甘油（10微克/分钟）可使P-50升高。在体外向中心静脉血中加入普萘洛尔（5×10⁻⁵摩尔/升至1×10⁻⁴摩尔/升）可使P-50显著升高。这些数据表明，普萘洛尔在体外可使P-50升高，但在体内则不然，而硝酸甘油在体内可使P-50升高，但在体外则不然。
