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择期腹主动脉手术的肺部危险因素。

Pulmonary risk factors of elective abdominal aortic surgery.

作者信息

Calligaro K D, Azurin D J, Dougherty M J, Dandora R, Bajgier S M, Simper S, Savarese R P, Raviola C A, DeLaurentis D A

机构信息

Section of Vascular Surgery, Pennsylvania Hospital, University of Pennsylvania School of Medicine.

出版信息

J Vasc Surg. 1993 Dec;18(6):914-20; discussion 920-1.

PMID:8264047
Abstract

PURPOSE

The purpose of this study was to retrospectively identify risk factors for postoperative pulmonary complications in patients undergoing elective abdominal aortic surgery via a midline incision.

METHODS

We reviewed 181 consecutive patients who underwent operation between July 1986 to December 1992. Preoperative factors analyzed included age, sex, diabetes mellitus, history of smoking, chronic obstructive pulmonary disease, obesity, indication for surgery (aneurysm [126] or aortoiliac occlusive disease [AIOD] [55]), history of coronary artery disease, length of preoperative hospital stay, American Society of Anaesthesiologists class, and pulmonary function tests. Intraoperative factors analyzed included endotracheal tube diameter, percent of inspired oxygen, blood loss, blood and crystalloid replacement, total operative time, epidural analgesia, and stress ulcer prophylaxis.

RESULTS

Although the operative mortality rate was only 1.7% (3 of 181), major pulmonary complications occurred in 29 (16%) patients, including two lung-related deaths. Pneumonia occurred in 17 (9%) patients, prolonged intubation greater than 24 hours occurred in nine (5%), and reintubation caused by pulmonary insufficiency occurred in three (2%). On univariate analysis, the following were associated with major pulmonary complications (p < 00.05): American Society of Anaesthesiologists class IV, age greater than 70 years, ideal body weight greater than 150%, forced vital capacity of 80% or less predicted, forced expiratory flow rate (25 to 75) of 60% or less predicted, crystalloid replacement greater than 6 L, and total operative time greater than 5 hours.

CONCLUSIONS

The presence of these pulmonary risk factors, notably increased age and weight, decreased forced vital capacity and forced expiratory flow rate (25 to 75), and expected prolonged operative time, influences our decision not to proceed with surgery for small aortic aneurysms or for AIOD causing claudication. Patients at high pulmonary risk with AIOD who require revascularization for limb salvage would be more likely to undergo extraanatomic bypass. Pulmonary risk factors may play as important a role as cardiac factors in elective aortic surgery.

摘要

目的

本研究旨在回顾性确定经中线切口行择期腹主动脉手术患者术后肺部并发症的危险因素。

方法

我们回顾了1986年7月至1992年12月期间连续接受手术的181例患者。分析的术前因素包括年龄、性别、糖尿病、吸烟史、慢性阻塞性肺疾病、肥胖、手术指征(动脉瘤[126例]或主-髂动脉闭塞性疾病[AIOD][55例])、冠状动脉疾病史、术前住院时间、美国麻醉医师协会分级以及肺功能测试。分析的术中因素包括气管导管直径、吸入氧百分比、失血量、血液和晶体液补充量、总手术时间、硬膜外镇痛以及应激性溃疡预防。

结果

尽管手术死亡率仅为1.7%(181例中有3例),但29例(16%)患者发生了严重肺部并发症,包括2例与肺部相关的死亡。17例(9%)患者发生肺炎,9例(5%)患者插管时间延长超过24小时,3例(2%)患者因肺功能不全再次插管。单因素分析显示,以下因素与严重肺部并发症相关(p<0.05):美国麻醉医师协会IV级、年龄大于70岁、理想体重超过150%、用力肺活量低于预测值的80%、用力呼气流量(25%至75%)低于预测值的60%、晶体液补充量超过6L以及总手术时间超过5小时。

结论

这些肺部危险因素的存在,尤其是年龄和体重增加、用力肺活量和用力呼气流量(25%至75%)降低以及预期手术时间延长,影响了我们对于小主动脉瘤或导致间歇性跛行的AIOD不进行手术的决定。因AIOD处于高肺部风险且需要血管重建以挽救肢体的患者更有可能接受解剖外旁路手术。在择期主动脉手术中,肺部危险因素可能与心脏因素起着同样重要的作用。

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