Behn U, van Hemmen J L, Sulzer B
Fachbereich Physik der Universität Leipzig, Germany.
J Theor Biol. 1993 Nov 7;165(1):1-25. doi: 10.1006/jtbi.1993.1173.
Memory to antigenic challenge of the immune system is described as a synergy of two components: cycles of interacting B cells in a dynamic equilibrium which store an internal image of an antigen, and long-lived memory B cells which stabilize the cycle that generates them. Small cycles are most relevant to the immune system's memory. The network is globally stable and supports Jerne's idea that suppression is important. Our model allows for exponential increase of antigens during the initial stage of infection. It has a number of stable fixed points, viz the virgin state, the healthy immunized state, and a state of chronic infection, the last occurring if the antigen is virulent enough. Numerical simulations show a difference between primary and secondary response and exhibit both predator-prey and intracycle oscillations. In the case of a chronic infection, the simulations suggest a specific stimulation therapy triggered by repeatedly injecting the antigens, thus making the infection acute. An optimal therapy is indicated.
处于动态平衡的相互作用的B细胞循环，其储存着抗原的内部影像；以及长寿记忆B细胞，其稳定产生它们的循环。小循环与免疫系统的记忆最为相关。该网络全局稳定，并支持耶尔恩关于抑制很重要的观点。我们的模型允许在感染初期抗原呈指数增长。它有多个稳定的固定点，即初始状态、健康免疫状态和慢性感染状态，若抗原毒性足够强则会出现最后一种状态。数值模拟显示了初次反应和二次反应之间的差异，并呈现出捕食者 - 猎物和循环内振荡。在慢性感染的情况下，模拟表明通过反复注射抗原触发特定的刺激疗法，从而使感染变为急性。给出了一种最优疗法。
