Faiman G, Ganguly P, Mehta A, Thliveris J A
Department of Anatomy, University of Manitoba, Winnipeg, Canada.
Mol Cell Biochem. 1993 Aug 11;125(1):27-33. doi: 10.1007/BF00926831.
We examined the effects of an aldose-reductase inhibitor, statil, which blocks the conversion of glucose to sorbitol, in rats rendered diabetic with streptozotocin in order to determine whether the anticipated changes in sorbitol content was associated with beneficial lack of changes in renal morphology and function. Groups of diabetic, insulin-treated and untreated rats were fed statil daily for a period of five months; each group was paired with a non-drug-treatment control group. At the conclusion of the study period, statil was not found to affect renal sorbitol concentrations nor did it effect functional or structural changes seen in the kidney. We conclude that further study, using other doses of statil and longer duration over which data is collected, must be undertaken in order to implicate the polyol pathway in the renal complications of diabetes mellitus.
我们研究了一种醛糖还原酶抑制剂——斯塔蒂尔（statil）的作用，它能阻止葡萄糖转化为山梨醇。我们将链脲佐菌素诱导糖尿病的大鼠作为研究对象，目的是确定山梨醇含量预期的变化是否与肾脏形态和功能未出现有益变化相关。将糖尿病大鼠、胰岛素治疗组大鼠和未治疗组大鼠分为几组，每天喂食斯塔蒂尔，持续五个月；每组均与一个非药物治疗对照组配对。在研究期结束时，发现斯塔蒂尔既不影响肾脏山梨醇浓度，也不影响在肾脏中观察到的功能或结构变化。我们得出结论，必须使用其他剂量的斯塔蒂尔并延长数据收集的持续时间进行进一步研究，以便将多元醇途径与糖尿病的肾脏并发症联系起来。
