Mizutani T, Teramoto A, Aruga T, Takakura K, Sanno N
Department of Neurosurgery, Showa General Hospital, Tokyo, Japan.
Neurosurgery. 1993 Nov;33(5):907-9; discussion 909-10. doi: 10.1227/00006123-199311000-00021.
Secreting pituitary adenomas have marked prevalence in pediatric adenomas. We described a case of an 11-year-old boy with pituitary null cell macroadenoma with silent macroscopic pituitary apoplexy. The patient was admitted with bitemporal hemianopsia and a gradual deterioration of visual acuity. An endocrinological study revealed a low concentration of testosterone and in the plasma a decreased response of luteinizing hormone and follicle-stimulating hormone to luteinizing hormone-releasing hormone. This patient may be the first case of prepubescent null cell macroadenoma confirmed with immunohistochemical study in addition to the findings of classical histopathology.
分泌性垂体腺瘤在儿童腺瘤中具有显著的患病率。我们描述了一例11岁男孩，患有垂体无功能大腺瘤并伴有无症状性肉眼可见的垂体卒中。该患者因双颞侧偏盲和视力逐渐下降入院。内分泌学检查显示血浆睾酮浓度低，黄体生成素和卵泡刺激素对促黄体生成素释放激素的反应降低。除了经典组织病理学的发现外，该患者可能是首例经免疫组织化学研究证实的青春期前无功能大腺瘤病例。
