Secco G B, Fardelli R, Campora E, Lapertosa G, Gentile R, Zoli S, Prior C
Istituto di Patologia Chirurgica, Università di Genova, Italia.
Oncology. 1994 Jan-Feb;51(1):30-4. doi: 10.1159/000227306.
Of 352 patients with colorectal carcinoma followed for a minimum of 5 years after surgery, 39 cases (11.1%; median age 60 years) had mucinous adenocarcinoma, and 4 (1.1%; median age 62 years) had signet-ring cell carcinoma. Mucinous carcinomas were most frequently located in the rectum (61.5%) and in the sigmoid colon (15.3%) and presented with stage C and D disease in 41 and 15% of the cases, respectively. Disease recurrence was more frequently observed in patients with mucinous (51.7%) or signet-ring lesions (100%) as compared with adenocarcinomas. Five-year survival was 45 (median 48 months), 28 (median 27), and 0% (median 15 months) in patients with adenocarcinomas, mucinous adenocarcinomas, and signet-ring cell carcinomas, respectively (p < 0.05). Mucinous carcinomas of the rectum had had a significantly worse prognosis (5-year survival 17%, median 33 months) as compared with adenocarcinomas of the same site (5-year survival 34%, median 25 months; p < 0.05).
在352例接受手术后至少随访5年的结直肠癌患者中，39例（11.1%；中位年龄60岁）为黏液腺癌，4例（1.1%；中位年龄62岁）为印戒细胞癌。黏液腺癌最常见于直肠（61.5%）和乙状结肠（15.3%），分别有41%和15%的病例表现为C期和D期疾病。与腺癌患者相比，黏液性（51.7%）或印戒样病变（100%）患者的疾病复发更为常见。腺癌、黏液腺癌和印戒细胞癌患者的5年生存率分别为45%（中位48个月）、28%（中位27个月）和0%（中位15个月）（p<0.05）。直肠黏液腺癌的预后明显比同一部位的腺癌差（5年生存率17%，中位33个月）（同一部位腺癌5年生存率34%，中位25个月；p<0.05）。
