Ogino S, Nose M, Irifune M, Kikumori H, Igarashi T
Department of Otolaryngology, Osaka University Medical School, Japan.
ORL J Otorhinolaryngol Relat Spec. 1993 Nov-Dec;55(6):352-5. doi: 10.1159/000276454.
The nasal mucociliary clearance was measured in 71 subjects with nasal allergy (NA) (56 subjects without sinusitis and 15 with sinusitis), 12 subjects with bronchial asthma (BA) (7 without, 5 with) and 7 subjects with aspirin-induced asthma (AIA) using a saccharin test. The results were compared with those obtained in a control group of 15 healthy subjects. The saccharin time (ST) values for both NA and BA subjects without sinusitis (16.9 +/- 9.9 and 20.1 +/- 9.4 min, respectively) did not differ from that of the healthy subjects (16.3 +/- 5.3 min). However, ST values in NA and BA subjects with sinusitis (37.6 +/- 22.9 and 57.0 +/- 6.7 min, respectively) were significantly higher than those of healthy subjects (p < 0.01). The ST value of AIA subjects (13.0 +/- 5.4 min) showed no significant difference compared with that of the control group. These results suggest that allergic reactions do not influence the nasal mucociliary clearance and that the property of mucus complicated with sinusitis is important. Also, sinusitis observed in AIA may be somewhat different from ordinary sinusitis complicated with NA and BA.
使用糖精试验对71例鼻过敏（NA）患者（56例无鼻窦炎，15例有鼻窦炎）、12例支气管哮喘（BA）患者（7例无鼻窦炎，5例有鼻窦炎）和7例阿司匹林诱发哮喘（AIA）患者的鼻黏液纤毛清除功能进行了测量。将结果与15名健康受试者组成的对照组的结果进行了比较。无鼻窦炎的NA和BA患者的糖精时间（ST）值（分别为16.9±9.9和20.1±9.4分钟）与健康受试者（16.3±5.3分钟）无差异。然而，有鼻窦炎的NA和BA患者的ST值（分别为37.6±22.9和57.0±6.7分钟）显著高于健康受试者（p<0.01）。AIA患者的ST值（13.0±5.4分钟）与对照组相比无显著差异。这些结果表明，过敏反应不影响鼻黏液纤毛清除功能，且合并鼻窦炎时黏液的性质很重要。此外，AIA患者中观察到的鼻窦炎可能与合并NA和BA的普通鼻窦炎有所不同。
