McKenzie M E, Conway D P, Logan N B, Wilkins C P, Chappel L R
Central Research Division, Pfizer Inc., Terre Haute, Indiana 47808.
Poult Sci. 1993 Nov;72(11):2052-7. doi: 10.3382/ps.0722052.
Semduramicin (AVIAX), a novel polyether ionophore, was titrated in a series of five battery tests at 20, 25, and 30 ppm in feed to determine the optimum level for use. Twelve-day-old broiler chicks were medicated for 48 h prior to inoculation in each 9-day test. The inocula included monospecific field isolates of Eimeria tenella, Eimeria brunetti, Eimeria necatrix, and Eimeria maxima, and a mixture of these species with Eimeria acervulina and Eimeria mitis. The numbers of oocysts inoculated were selected after titration of each species and the mixture of species. All three concentrations of semduramicin significantly (P < .05) reduced coccidiosis mortality and lesion scores and achieved lower feed:gain ratios and greater weight gains than the infected, unmediated treatments. A concentration of 25 ppm semduramicin was determined to be optimal based on improved lesion control compared with 20 ppm and improved weight gain compared with 30 ppm.
赛杜霉素（AVIAX）是一种新型聚醚离子载体抗生素，在一系列五项组试验中，以20、25和30 ppm的浓度添加到饲料中进行滴定，以确定最佳使用水平。在每项为期9天的试验中，12日龄的肉鸡在接种前用药48小时。接种物包括柔嫩艾美耳球虫、布氏艾美耳球虫、毒害艾美耳球虫和巨型艾美耳球虫的单特异性田间分离株，以及这些种类与堆型艾美耳球虫和微小艾美耳球虫的混合物。在对每种球虫及球虫混合物进行滴定后，确定接种卵囊的数量。与未用药的感染组相比，所有三种浓度的赛杜霉素均显著（P < 0.05）降低了球虫病死亡率和病变评分，并实现了更低的料重比和更高的体重增加。基于与20 ppm相比改善的病变控制以及与30 ppm相比改善的体重增加，确定25 ppm的赛杜霉素浓度为最佳浓度。
