Glaziou P, Martin P M
Institut Territorial de Recherches Médicales Louis Malardé, Papeete, Tahiti, French Polynesia.
Toxicon. 1993 Sep;31(9):1151-4. doi: 10.1016/0041-0101(93)90130-b.
A 1-year observational study of all standardized medical records of ciguatera fish poisoning notified cases was conducted in French Polynesia. The objective was to determine the factors that influence the clinical response to ciguatera fish poisoning. During the year 1991, there were 551 cases notified on standardized code sheets by physicians (notification rate 276 per 100,000). The mean age was 36.6 years (S.D. 15.6). The largest age group was that between 30 and 49 years old (notification rate 562 per 100,000). The gender ratio (M/F) was 1.6. Of the 551 cases, 257 (47%) presented with a history of a previous attack. A clinical score was calculated to assess the outcome for each case. The adjusted odds ratio (OR) for a severe disease (33% with a score greater than 5) was significantly increased when the fish ingested was carnivorous (OR = 1.62, P = 0.02) and when a history of a previous attack was reported (OR = 1.71, P = 0.006). The increased severity of multiple episodes and the increase of the notification rate with age suggest a possible accumulation of toxin in the human organism.
在法属波利尼西亚对所有雪卡毒素中毒通报病例的标准化医疗记录进行了为期1年的观察性研究。目的是确定影响雪卡毒素中毒临床反应的因素。1991年期间，医生在标准化编码表上通报了551例病例（通报率为每10万人276例）。平均年龄为36.6岁（标准差15.6）。最大年龄组为30至49岁（通报率为每10万人562例）。性别比（男/女）为1.6。在551例病例中，257例（47%）有既往发作史。计算了临床评分以评估每个病例的结果。当摄入的鱼为肉食性时（比值比=1.62，P=0.02）以及报告有既往发作史时（比值比=1.71，P=0.006），严重疾病（评分大于5分的占33%）的调整后比值比显著升高。多次发作严重程度增加以及通报率随年龄增长，提示毒素可能在人体中蓄积。
