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[前列腺癌危险因素的研究]

[Study of risk factors for prostatic cancer].

作者信息

Nakata S, Imai K, Yamanaka H

机构信息

Department of Urology, Gunma University School of Medicine.

出版信息

Hinyokika Kiyo. 1993 Nov;39(11):1017-24; discussion 1024-5.

PMID:8266869
Abstract

A case-control study was conducted on 294 prostatic cancer patients and controls. General population controls were chosen from 13 areas in Gunma Prefecture and were matched by age (+/- 2 y.o.) to cases. Odds ratio (O.R.) and 95% confidence interval (C.I.) were calculated on each item according to group; 69 years old or younger and 70 years old or older, and age-adjusted O.R. and 95% C.I. were calculated. Risk factors of prostatic cancer were investigated. There was a significantly higher risk for prostatic cancer in those 1) engaged in agriculture, forestry or fishery (< or = 69, > or = 70, total), 2) shaving 1/3 days or less frequently (> or = 70, total), 3) having thin pubic hair (total), 4) phimosis (< or = 69, total), 5) having history of smoking (> or = 70, total), 6) history of smoking 50 years or more (total), 7) having eaten vegetables rarely (> or = 70, total), 8) having past history or complication of asthma (> or = 70). O.R.s of having past history or complication of benign prostatic hypertrophy, prostatitis and urethral stricture were high significantly, but they were supposed to be caused by bias. Four patients had first degree family members who suffered from prostatic cancer, compared to zero in the control. There was a significantly lower risk for prostatic cancer in those 1) engaged in office work (> or = 70, total), 2) blood type A or AB (< or = 69), 3) having had one child or none (total), 4) having past history or complication of tuberculosis (total).(ABSTRACT TRUNCATED AT 250 WORDS)

摘要

对294例前列腺癌患者及对照进行了一项病例对照研究。一般人群对照选自群马县的13个地区,并按年龄(±2岁)与病例进行匹配。根据分组对每个项目计算比值比(O.R.)和95%置信区间(C.I.);分为69岁及以下和70岁及以上,并计算年龄调整后的O.R.和95% C.I.。对前列腺癌的危险因素进行了调查。前列腺癌风险显著较高的人群有:1)从事农业、林业或渔业工作的人(69岁及以下、70岁及以上、总体);2)剃须频率为1/3天或更低的人(70岁及以上、总体);3)阴毛稀疏的人(总体);4)包茎患者(69岁及以下、总体);5)有吸烟史的人(70岁及以上、总体);6)吸烟史达50年或更长时间的人(总体);7)很少吃蔬菜的人(70岁及以上、总体);8)有哮喘既往史或并发症的人(70岁及以上)。良性前列腺增生、前列腺炎和尿道狭窄既往史或并发症的O.R.值显著较高,但推测是由偏倚引起的。4例患者有患前列腺癌的一级家庭成员,而对照组为零。前列腺癌风险显著较低的人群有:1)从事办公室工作的人(70岁及以上、总体);2)A型或AB型血的人(69岁及以下);3)育有一个孩子或没有孩子的人(总体);4)有结核病既往史或并发症的人(总体)。(摘要截断于250字)

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Associations between estrogen receptor genetic polymorphisms, smoking status, and prostate cancer risk: a case-control study in Japanese men.雌激素受体基因多态性、吸烟状况与前列腺癌风险之间的关联:一项针对日本男性的病例对照研究。
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Chronic immune activation and inflammation as the cause of malignancy.慢性免疫激活和炎症作为恶性肿瘤的病因。
Br J Cancer. 2001 Aug 17;85(4):473-83. doi: 10.1054/bjoc.2001.1943.
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[Work-related risk factors of prostate carcinoma: results of a case-control study].[前列腺癌的工作相关危险因素:一项病例对照研究的结果]
Soz Praventivmed. 1998;43(6):282-92. doi: 10.1007/BF01299716.