Lopez J A, Jarow J P
Department of Urology, Bowman Gray School of Medicine of Wake Forest University, Winston-Salem, North Carolina.
J Urol. 1993 Jan;149(1):53-5. doi: 10.1016/s0022-5347(17)35997-9.
A penile vascular evaluation was performed upon 95 consecutive men with Peyronie's disease (19 potent and 76 impotent) and 100 consecutive impotent men without Peyronie's disease to gain further understanding of the pathophysiology of erectile dysfunction in patients with Peyronie's disease. Only 1 of the 19 potent patients with Peyronie's disease had abnormal arterial blood flow by duplex ultrasonography and none had evidence of veno-occlusive dysfunction by either duplex ultrasonography or dynamic infusion cavernosometry/cavernosography. In contrast, 36% of the impotent men with Peyronie's disease had abnormal arterial blood flow and 59% had evidence of veno-occlusive dysfunction. There was no significant difference in historical risk factors for impotence between the impotent patients with Peyronie's disease and the control population of impotent patients. However, the presence of veno-occlusive dysfunction in the control population (16%) was significantly less than that of the impotent Peyronie's disease patients (p < 0.001). Although patients with Peyronie's disease may suffer impotence due to arterial occlusive disease, our results indicate that the principal cause of impotence in this patient population is veno-occlusive dysfunction.
对95例连续性佩罗尼氏病患者（19例有勃起功能、76例无勃起功能）以及100例连续性无佩罗尼氏病的勃起功能障碍男性进行阴茎血管评估，以进一步了解佩罗尼氏病患者勃起功能障碍的病理生理学。19例有勃起功能的佩罗尼氏病患者中，仅1例经双功超声检查显示动脉血流异常，且无论是双功超声检查还是动态海绵体灌注测压/海绵体造影检查，均无静脉闭塞功能障碍的证据。相比之下，76例无勃起功能的佩罗尼氏病患者中，36%有动脉血流异常，59%有静脉闭塞功能障碍的证据。佩罗尼氏病无勃起功能患者与勃起功能障碍对照人群在导致勃起功能障碍的既往危险因素方面无显著差异。然而，对照人群中静脉闭塞功能障碍的发生率（16%）显著低于佩罗尼氏病无勃起功能患者（p<0.001）。虽然佩罗尼氏病患者可能因动脉闭塞性疾病而出现勃起功能障碍，但我们的结果表明，该患者群体勃起功能障碍的主要原因是静脉闭塞功能障碍。
