Colquhoun I W, Berg G A, el-Fiky M, Hurle A, Fell G S, Wheatley D J
University Department of Cardiac Surgery, Glasgow Royal Infirmary, UK.
Eur J Cardiothorac Surg. 1993;7(10):520-3. doi: 10.1016/1010-7940(93)90049-h.
One hundred and thirty patients undergoing elective myocardial revascularisation were randomised to receive an intravenous infusion containing either 50 mmol magnesium chloride or placebo during the first 48 h following surgery. Magnesium was given to 66 patients and a placebo infusion to 64 patients. Postoperative serum magnesium concentrations fell in the placebo group (from 0.83 +/- 0.06 to 0.79 +/- 0.11 mmol/l) but were elevated in the magnesium group (from 0.82 +/- 0.05 to 1.2 +/- 0.25 mmol/l). In total, 35 patients (26.9%) had a supraventricular arrhythmia, of which 11 were in the magnesium group (16.7%) and 24 (37.5%) in the placebo group (P = 0.013). Three patients in the magnesium group had an episode of ventricular fibrillation and three patients in the placebo group had frequent ventricular ectopics. There was one death in the magnesium group associated with a perioperative myocardial infarction. This study shows that intravenous magnesium supplements reduce the incidence of supraventricular arrhythmias following coronary artery surgery.
130例行择期心肌血运重建术的患者在术后48小时内被随机分为两组，分别接受含50 mmol氯化镁的静脉输注或安慰剂。66例患者接受镁治疗，64例患者接受安慰剂输注。安慰剂组术后血清镁浓度下降（从0.83±0.06降至0.79±0.11 mmol/L），而镁组血清镁浓度升高（从0.82±0.05升至1.2±0.25 mmol/L）。共有35例患者（26.9%）发生室上性心律失常，其中镁组11例（16.7%），安慰剂组24例（37.5%）（P = 0.013）。镁组有3例患者发生心室颤动，安慰剂组有3例患者频发室性早搏。镁组有1例死亡与围手术期心肌梗死有关。本研究表明，静脉补充镁可降低冠状动脉手术后室上性心律失常的发生率。
