Higuchi T, Fernandez E J, Maudsley A A, Weiner M W
Department of Veterans Affairs Medical Center, University of California at San Francisco 94121.
NMR Biomed. 1993 Sep-Oct;6(5):311-7. doi: 10.1002/nbm.1940060505.
The goal of this study was to examine metabolic differences between cortex and basal ganglia in normal rat brain and to determine postmortem changes using in vivo 1H magnetic resonance spectroscopic imaging at 300 MHz. The resonances observed were: choline, creatine + phosphocreatine, N-acetyl aspartate (NAA), lactate (Lac), and three small resonances in the amino acid region which included resonances from aspartate + NAA (Asp), glutamine + NAA (Gln), and glutamate + GABA (Glu). A previously unassigned resonance was observed at 1.13 ppm in brain of rats anesthetized with pentobarbital. Spectroscopic images in normal brain demonstrated increased NAA and Gln and decreased Glu in cortex compared to basal ganglia. The major postmortem changes were an increase of Lac, Glu and Cho and a decrease of NAA and Asp. The rise in Lac was significantly higher in cortex than in basal ganglia.
本研究的目的是检测正常大鼠脑皮质和基底神经节之间的代谢差异，并使用300MHz的体内1H磁共振波谱成像确定死后变化。观察到的共振峰包括：胆碱、肌酸+磷酸肌酸、N-乙酰天门冬氨酸（NAA）、乳酸（Lac）以及氨基酸区域的三个小共振峰，其中包括天门冬氨酸+NAA（Asp）、谷氨酰胺+NAA（Gln）和谷氨酸+γ-氨基丁酸（Glu）的共振峰。在用戊巴比妥麻醉的大鼠脑中，在1.13ppm处观察到一个先前未归属的共振峰。正常脑的波谱成像显示，与基底神经节相比，皮质中的NAA和Gln增加，Glu减少。主要的死后变化是Lac、Glu和Cho增加，NAA和Asp减少。皮质中Lac的升高明显高于基底神经节。
