Giegé R, Florentz C, Dreher T W
Unité Structure des Macromolécules Biologiques et Mécanismes de Reconnaissance, Institut de Biologie Moléculaire et Cellulaire du Centre National de la Recherche Scientifique, Strasbourg, France.
Biochimie. 1993;75(7):569-82. doi: 10.1016/0300-9084(93)90063-x.
The genomic RNA from turnip yellow mosaic virus presents a 3'-end functionally and structurally related to tRNAs. This report summarizes our knowledge about the peculiar structure of the tRNA-like domain and its interaction with tRNA specific proteins, like RNAse P, tRNA nucleotidyl-transferase, aminoacyl-tRNA synthetases, and elongation factors. It discusses also the biological role of this structure in the viral life cycle. A brief survey of our knowledge of other tRNA mimicries in biological systems, as well as their relevance for understanding canonical tRNA, will also be presented.
芜菁黄花叶病毒的基因组RNA具有一个在功能和结构上与tRNA相关的3'末端。本报告总结了我们对tRNA样结构域独特结构及其与tRNA特异性蛋白(如核糖核酸酶P、tRNA核苷酸转移酶、氨酰-tRNA合成酶和延伸因子)相互作用的了解。它还讨论了这种结构在病毒生命周期中的生物学作用。此外,还将简要概述我们对生物系统中其他tRNA模拟物的了解,以及它们与理解经典tRNA的相关性。