系统性红斑狼疮患者中白细胞介素-2、白细胞介素-2受体（CD25+）、可溶性白细胞介素-2受体及白细胞介素-4与疾病活动度的关系

Relationship of IL-2, IL-2R (CD25+), soluble IL-2R and IL-4 with disease activity in SLE patients.

作者信息

Cuadrado M J, Marubayashi M, Ortega C, Fernandez-Arcas N, Garcia-Cozar F, Pena J, Sanchez-Guijo P, Santamaria M

机构信息

Unit of Rheumatology, Hospital Universitario Reina Sofia, Facultad de Medicina, Universidad de Cordoba, Spain.

出版信息

Lupus. 1993 Aug;2(4):257-60. doi: 10.1177/096120339300200113.

DOI:10.1177/096120339300200113

PMID:8268974

Abstract

The plasma levels of interleukin-4 (IL-4), interleukin-2 (IL-2), soluble receptor of IL-2 (IL-2R) and T cell expression of IL-2 receptor chain (CD25+) were determined in an attempt to relate these parameters with disease activity in systemic lupus erythematosus (SLE). IL-4, IL-2 and sIL-2R plasma levels of SLE patients were significantly higher than those of the control group (P < 0.05) while CD25+ expression was similar in both groups. Only sIL-2R levels were significantly higher (P < 0.05) in active than in inactive patients.

摘要

为了将这些参数与系统性红斑狼疮（SLE）的疾病活动度相关联，我们测定了白细胞介素-4（IL-4）、白细胞介素-2（IL-2）、IL-2可溶性受体（IL-2R）的血浆水平以及IL-2受体链（CD25+）的T细胞表达。SLE患者的IL-4、IL-2和sIL-2R血浆水平显著高于对照组（P < 0.05），而两组的CD25+表达相似。仅sIL-2R水平在活动期患者中显著高于非活动期患者（P < 0.05）。