可溶性白细胞介素2受体与系统性红斑狼疮患者临床症状的关系。
Relation between soluble interleukin 2 receptor and clinical findings in patients with systemic lupus erythematosus.
作者信息
Tokano Y, Murashima A, Takasaki Y, Hashimoto H, Okumura K, Hirose S
机构信息
Department of Internal Medicine, Juntendo University School of Medicine, Tokyo, Japan.
出版信息
Ann Rheum Dis. 1989 Oct;48(10):803-9. doi: 10.1136/ard.48.10.803.
The concentration of soluble interleukin 2 receptor (IL-2R) was determined in the serum of 54 patients with systemic lupus erythematosus (SLE) by an enzyme linked immunosorbent assay (ELISA) using two monoclonal antibodies with the IL-2R. Concentrations of soluble IL-2R in the serum of the patients with SLE (study group) were significantly higher than in 20 normal subjects (control group). The relation between concentrations of soluble IL-2R and clinical findings was investigated. The concentration of soluble IL-2R showed no particular relation with the clinical manifestations and did not correlate with the level of anti-DNA antibody or CH50. Significant correlation between the concentration of soluble IL-2R and disease activity did exist, however. Furthermore, the concentration of soluble IL-2R in some cases changed simultaneously with the disease activity. Thus the concentration of soluble IL-2R may serve as a new clinical indicator of disease activity in patients with SLE.
采用两种抗白细胞介素2受体（IL-2R）单克隆抗体，通过酶联免疫吸附测定法（ELISA）测定了54例系统性红斑狼疮（SLE）患者血清中可溶性白细胞介素2受体（IL-2R）的浓度。SLE患者（研究组）血清中可溶性IL-2R的浓度显著高于20名正常受试者（对照组）。研究了可溶性IL-2R浓度与临床症状之间的关系。可溶性IL-2R的浓度与临床表现无特定关系，与抗DNA抗体水平或CH50无关。然而，可溶性IL-2R浓度与疾病活动度之间确实存在显著相关性。此外，在某些情况下，可溶性IL-2R的浓度随疾病活动度同时变化。因此，可溶性IL-2R的浓度可能作为SLE患者疾病活动度的一种新的临床指标。
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