Adams P M, Barratt E S
Psychopharmacology (Berl). 1976 Jul 28;48(2):205-7. doi: 10.1007/BF00423262.
Following a 30-day baseline, 60 days of sodium pentobarbital treatment (5 mg/kg) were given to squirrel monkeys 2 h prior to the start of a 12-h recording of EEG and EOG. Following the drug-treatment phase, an additional 30-day period was used to determine the rate of recovery. Repeated pentobarbital treatment significantly reduced awake time and slow wave sleep while it elevated the time spent in drowsy and light sleep. The recovery phase indicated a brief recovery of rapid eye movement sleep while the other stages failed to return to baseline levels. The cyclical nature of the changes observed with chronic pentobarbital suggest the importance of circadian fluctuations in the study of chronic drug treatment and the sleep-wakefulness process.
在30天的基线期之后，在开始对松鼠猴进行12小时脑电图（EEG）和眼电图（EOG）记录前2小时，给予它们60天的戊巴比妥钠治疗（5毫克/千克）。在药物治疗阶段之后，再用30天来确定恢复率。重复戊巴比妥治疗显著减少了清醒时间和慢波睡眠，同时增加了昏昏欲睡和浅睡眠的时间。恢复阶段表明快速眼动睡眠有短暂恢复，而其他阶段未能恢复到基线水平。慢性戊巴比妥治疗所观察到的变化的周期性表明，昼夜节律波动在慢性药物治疗和睡眠-觉醒过程的研究中具有重要意义。
