Fazekas T, Scherlag B J, Vos M, Wellens H J, Lazzara R
Department of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City 73190.
Clin Cardiol. 1993 Nov;16(11):768-74. doi: 10.1002/clc.4960161105.
Magnesium is an essential transmembrane and intracellular modulator of the electrical activity of cardiac cells. This review provides an up-to-date consideration of the cellular and clinical electrophysiological role of magnesium. This ubiquitous element seems to be important from both the theoretical and clinical point of view, because magnesium salts (MgSO4, MgCl2) administered intravenously are particularly effective in those arrhythmias in which the mechanism involves early or delayed after depolarization-induced triggered activity. The authors share the view that I.V. magnesium is the drug of choice in "torsade de pointes" ventricular tachycardia accompanying acquired long QT/QTU syndrome. It is complementary therapeutic agent in digitalis-induced tachycardias. Further studies are needed to elucidate magnesium's mode of action and efficacy in other types of clinical tachyarrhythmias.
镁是心脏细胞电活动的一种重要跨膜和细胞内调节剂。本综述对镁的细胞和临床电生理作用进行了最新的探讨。这种普遍存在的元素从理论和临床角度来看似乎都很重要，因为静脉注射镁盐（MgSO4、MgCl2）在那些机制涉及早期或延迟后去极化诱导的触发活动的心律失常中特别有效。作者们一致认为，静脉注射镁是伴有获得性长QT/QTU综合征的“尖端扭转型”室性心动过速的首选药物。它是洋地黄引起的心动过速的辅助治疗药物。需要进一步研究以阐明镁在其他类型临床快速性心律失常中的作用方式和疗效。
