Zhang S B, Wang L S, He P
Department of Internal Medicine, First Affiliated Hospital, Beijing Medical University.
Zhonghua Nei Ke Za Zhi. 1993 Jun;32(6):381-3.
Five patients with the diagnosis of cardiac amyloidosis established by autopsy and biopsy of noncardiac tissue were reported. All of the patients had cardiac dysfunction. Echocardiogram showed symmetrical thickness of left ventricle, increase of heart weight and reduction of left ventricular ejection fraction. Only two cases had "granular sparkling" on the ventricular wall. The clinical findings of cardiac amyloidosis are arrhythmias, conduction disturbances and intractable heart failure. Echocardiographic examination may reveal cardiac involvement and severity of pathological involvement and predict prognosis. The "granular sparkling" is not a specific feature for the diagnosis of cardiac amyloidosis. Biopsy of either noncardiac or cardiac tissue is required for correct diagnosis.
报告了5例经尸检及非心脏组织活检确诊为心脏淀粉样变性的患者。所有患者均有心脏功能障碍。超声心动图显示左心室壁厚度对称、心脏重量增加及左心室射血分数降低。仅2例心室壁有“颗粒样闪烁”表现。心脏淀粉样变性的临床表现为心律失常、传导障碍及难治性心力衰竭。超声心动图检查可发现心脏受累情况及病理累及的严重程度，并可预测预后。“颗粒样闪烁”并非心脏淀粉样变性诊断的特异性特征。正确诊断需要进行非心脏或心脏组织活检。
