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核心技术专利：CN118964589B侵权必究

核心技术专利：CN118964589B侵权必究

Brandan E, Inestrosa N C

Department of Cell and Molecular Biology, Faculty of Biological Sciences, Catholic University of Chile, Santiago.

Gen Pharmacol. 1993 Sep;24(5):1063-8. doi: 10.1016/0306-3623(93)90350-7.

There has been an enormous amount of information relating to the molecular components involved in Alzheimer's disease. 2. Recently some attention has been focused on the extracellular matrix (ECM) components present in the brain amyloid deposits. 3. Here we discuss, the direct involvement of ECM constituents such as laminin, collagen type IV, fibronectin, proteoglycans (PGs) and basic fibroblast growth factor in the formation of neuritic plaques. 4. We suggest that PGs act as nucleating agents in the formation of the diffuse amyloid deposits that precede the formation of the neuritic plaque in the brain of patients affected with Alzheimer's disease.

已经有大量与阿尔茨海默病所涉及的分子成分相关的信息。2. 最近，一些注意力集中在了脑淀粉样沉积物中存在的细胞外基质（ECM）成分上。3. 在此我们讨论细胞外基质成分如层粘连蛋白、IV型胶原、纤连蛋白、蛋白聚糖（PGs）和碱性成纤维细胞生长因子在神经炎性斑块形成中的直接作用。4. 我们认为，在阿尔茨海默病患者大脑中，蛋白聚糖在神经炎性斑块形成之前的弥漫性淀粉样沉积物形成过程中充当成核剂。

Brandan E, Inestrosa N C

Department of Cell and Molecular Biology, Faculty of Biological Sciences, Catholic University of Chile, Santiago.

Gen Pharmacol. 1993 Sep;24(5):1063-8. doi: 10.1016/0306-3623(93)90350-7.

There has been an enormous amount of information relating to the molecular components involved in Alzheimer's disease. 2. Recently some attention has been focused on the extracellular matrix (ECM) components present in the brain amyloid deposits. 3. Here we discuss, the direct involvement of ECM constituents such as laminin, collagen type IV, fibronectin, proteoglycans (PGs) and basic fibroblast growth factor in the formation of neuritic plaques. 4. We suggest that PGs act as nucleating agents in the formation of the diffuse amyloid deposits that precede the formation of the neuritic plaque in the brain of patients affected with Alzheimer's disease.

已经有大量与阿尔茨海默病所涉及的分子成分相关的信息。2. 最近，一些注意力集中在了脑淀粉样沉积物中存在的细胞外基质（ECM）成分上。3. 在此我们讨论细胞外基质成分如层粘连蛋白、IV型胶原、纤连蛋白、蛋白聚糖（PGs）和碱性成纤维细胞生长因子在神经炎性斑块形成中的直接作用。4. 我们认为，在阿尔茨海默病患者大脑中，蛋白聚糖在神经炎性斑块形成之前的弥漫性淀粉样沉积物形成过程中充当成核剂。