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核心技术专利：CN118964589B侵权必究

核心技术专利：CN118964589B侵权必究

Segarra J, Santafé J, Garrido M, Martínez de Ibarreta M J

Departmento de Farmacología, Facultad de Farmacia, Universidad del País Vasco, Vitoria, Spain.

Gen Pharmacol. 1993 Sep;24(5):1163-71. doi: 10.1016/0306-3623(93)90364-4.

The time-course of the ocular effects of topical verapamil and nifedipine as well as the dose-response relationship, were studied in conscious, normotensive rabbits. 2. Both drugs caused a dose-dependent fall of intraocular pressure, which lasted 4 hr or more. 3. Log dose-response curves of both drugs show a similar peak response, but the potency of verapamil was greater that of nifedipine. 4. A fall in the intraocular pressure in the untreated eye was also observed. 5. Verapamil and nifedipine induced a reduction of the tonographic outflow facility in the treated eye.

在清醒的正常血压家兔中研究了局部应用维拉帕米和硝苯地平的眼部效应的时间进程以及剂量反应关系。2. 两种药物均引起眼压剂量依赖性下降，持续4小时或更长时间。3. 两种药物的对数剂量反应曲线显示出相似的峰值反应，但维拉帕米的效力大于硝苯地平。4. 在未治疗的眼中也观察到眼压下降。5. 维拉帕米和硝苯地平导致治疗眼的眼压描记流出易度降低。

Segarra J, Santafé J, Garrido M, Martínez de Ibarreta M J

Departmento de Farmacología, Facultad de Farmacia, Universidad del País Vasco, Vitoria, Spain.

Gen Pharmacol. 1993 Sep;24(5):1163-71. doi: 10.1016/0306-3623(93)90364-4.

The time-course of the ocular effects of topical verapamil and nifedipine as well as the dose-response relationship, were studied in conscious, normotensive rabbits. 2. Both drugs caused a dose-dependent fall of intraocular pressure, which lasted 4 hr or more. 3. Log dose-response curves of both drugs show a similar peak response, but the potency of verapamil was greater that of nifedipine. 4. A fall in the intraocular pressure in the untreated eye was also observed. 5. Verapamil and nifedipine induced a reduction of the tonographic outflow facility in the treated eye.

在清醒的正常血压家兔中研究了局部应用维拉帕米和硝苯地平的眼部效应的时间进程以及剂量反应关系。2. 两种药物均引起眼压剂量依赖性下降，持续4小时或更长时间。3. 两种药物的对数剂量反应曲线显示出相似的峰值反应，但维拉帕米的效力大于硝苯地平。4. 在未治疗的眼中也观察到眼压下降。5. 维拉帕米和硝苯地平导致治疗眼的眼压描记流出易度降低。