Iwasaki H, Müller H, Stutte H J, Brennscheidt U
Virchows Arch A Pathol Anat Histopathol. 1984;405(1):41-53. doi: 10.1007/BF00694924.
Forty three cases of palmar fibromatosis were studied by light and electron microscopy, enzyme histochemistry, and ultrastructural immunohistochemistry. By electron microscopy most of the cells composing the nodules in both the proliferative and the involutional stages were identical to myofibroblasts. The myofibroblasts in the involutional nodules often possessed microfilament aggregates probably representing contraction of micro(actin)filaments in the cytoplasm. The proliferative nodules revealed small perivascular haemorrhages and haemosiderin deposits accompanied by accumulation of macrophages and some lymphocytes; these inflammatory cells possibly secrete a certain growth factor inducing proliferation of genetically abnormal fibroblasts and myofibroblasts. Diaminopeptidase IV was detected in myofibroblasts and fibroblasts by enzyme histochemistry and ultrastructural immunohistochemistry; the enzyme may play a role in the metabolism of intercellular substances. Some perivascular mesenchymal cells, interpreted as variants of myofibroblasts, had moderate activity of alkaline phosphatase.
对43例掌腱膜纤维瘤病进行了光镜、电镜、酶组织化学及超微结构免疫组织化学研究。电镜下，增殖期和消退期结节中的大多数细胞均与肌成纤维细胞相同。消退期结节中的肌成纤维细胞常含有微丝聚集体，可能代表细胞质中微（肌动蛋白）丝的收缩。增殖期结节可见小的血管周围出血和含铁血黄素沉积，伴有巨噬细胞和一些淋巴细胞聚集；这些炎性细胞可能分泌某种生长因子，诱导基因异常的成纤维细胞和肌成纤维细胞增殖。通过酶组织化学和超微结构免疫组织化学在肌成纤维细胞和成纤维细胞中检测到二肽基肽酶IV；该酶可能在细胞间物质代谢中起作用。一些血管周围间充质细胞被解释为肌成纤维细胞的变体，具有中等活性的碱性磷酸酶。
