Sikorskaia Ia V, Azybekov R, Shtyka O M
Khirurgiia (Mosk). 1993 Jul(7):13-6.
The authors analysed the course of the disease in 903 patients with gastric ulcer and in 406 cases of gastric carcinoma which developed in patients suffering from peptic ulcer. Among 345 patients who did not undergo operation, in 24 (7%) carcinoma occurred in the edge of the ulcer or in the cicatrix. Initial stages (I-II) were revealed in 19 patients. Dysplasia of the mucous membrane was found in most patients 1-9 years before the occurrence of carcinoma. Patients with gastric ulcer belong to the risk group. The risk is highest in II and III degree dysplasia and atrophic gastritis. In III degree dysplasia surgical treatment must be considered.
作者分析了903例胃溃疡患者以及406例在消化性溃疡患者中发生的胃癌患者的疾病进程。在345例未接受手术的患者中,有24例(7%)在溃疡边缘或瘢痕处发生了癌变。19例患者处于疾病早期(I-II期)。大多数患者在癌变发生前1-9年出现了黏膜发育异常。胃溃疡患者属于风险人群。在II级和III级发育异常以及萎缩性胃炎患者中风险最高。对于III级发育异常患者,必须考虑手术治疗。