[促甲状腺激素和甲状腺激素影响下大鼠和豚鼠哈德氏腺的酶组织化学研究（作者译）]

[Enzymhistochemical investigations on the Harderian gland of rat and guinea pig under the influence of TSH and thyrohormones (author's transl)].

作者信息

Jostes H

出版信息

Acta Histochem. 1976;57(1):127-56. doi: 10.1016/s0065-1281(76)80014-1.

Abstract

After application of TSH, trijodthyronine and thyroxine enzyme histochemical investigations were carried out on the Harderian glands of albino rats and guinea pigs. Marked changes were seen after a treatment of 9 days with TSH. Thereby in B-cells of rat appeared big vacuoles, which were clearly to be seen after oxidoreductase-reactions, but hardly to be seen after hydrolase-reactions. In guinea pigs the cells of the gland are strongly vacuolised both in controls and in treated animals. But this last group shows a great hypertrophy of the gland with widening of tubuli and acini. In both species of animals the steroid-3-beta-ol-dehydrogenase-reaction is negative. Nomenclature, specific reactions of the animals treated with hormones, function of the Harderian gland and its relevance in investigations of experimental exophthalmos are discussed.

摘要

应用促甲状腺激素（TSH）后，对白化大鼠和豚鼠的哈德氏腺进行了三碘甲状腺原氨酸和甲状腺素的酶组织化学研究。用TSH处理9天后观察到明显变化。因此，大鼠的B细胞出现大液泡，在氧化还原酶反应后清晰可见，但在水解酶反应后几乎不可见。在豚鼠中，无论是对照动物还是处理动物，腺细胞都强烈空泡化。但后一组显示腺体明显肥大，小管和腺泡增宽。在这两种动物中，类固醇-3-β-醇脱氢酶反应均为阴性。讨论了命名法、激素处理动物的特异性反应、哈德氏腺的功能及其在实验性突眼症研究中的相关性。