Salvador M, Berthoumieu H, Louvet J P, Conte J J, Guittard J, Suc J M
Arch Mal Coeur Vaiss. 1976 Nov;69(11):1155-61.
The course of mean arterial pressure was compared in two series concerning 18 primary or tumoral hyperaldosteronism and 8 idiopathic ones. Identification of the nature of the hyperaldosteronism should not yet motivate a decision on principle, surgical in case of tumor, medical in an idiopathic case. In the latter case cooperation and tolerance of medical treatment, severity of hypertension also come into consideration. A positive spirolactone test, a hypertension course of less than six years were in our experience a good indication of successful surgery, as opposed to a normal unilateral renal biopsy. In case of operation, the removal protocol should adapt to the peroperative findings; 80% adrenalectomy is the most common procedure, except in the case of isolated adenoma of more than 10 mm diameter.
对两组患者的平均动脉压病程进行了比较,一组为18例原发性或肿瘤性醛固酮增多症患者,另一组为8例特发性醛固酮增多症患者。醛固酮增多症性质的确定目前不应成为原则性决策的依据,即肿瘤性患者进行手术,特发性患者进行药物治疗。在后一种情况下,还需考虑药物治疗的合作性和耐受性以及高血压的严重程度。根据我们的经验,螺内酯试验阳性、高血压病程少于六年是手术成功的良好指征,这与单侧肾脏活检正常的情况相反。如果进行手术,切除方案应根据术中发现进行调整;除直径大于10mm的孤立性腺瘤外,80%肾上腺切除术是最常见的手术方式。