淋病奈瑟菌多重耐药性的流行情况
Prevalence of multiple antibiotic resistance in Neisseria gonorrhoeae.
作者信息
Platt D J
出版信息
Br J Vener Dis. 1976 Dec;52(6):384-6. doi: 10.1136/sti.52.6.384.
Abstract
The susceptibility of 100 strains of Neisseria gonorrhoeae to five antimicrobial agents (penicillin, streptomycin, oxytetracycline, sulphamethoxazole, and gentamicin) was examined. Three strains were resistant to each antimicrobial, fourteen exhibited resistance to three or four of the five compounds tested, and 49 were resistant to a single agent, or to pairs of the selected agents. 34 strains were found to be fully sensitive to all of the compounds tested. It is suggested that resistance to gentamicin and sulphamethoxazole may be determined by a multiple resistance gene. The overall frequency of penicillin resistance was found to be 26-5 per cent (MIC greater than 0-06 mug/ml.), suggesting a significant decrease in resistance since 1968.
摘要
检测了100株淋病奈瑟菌对五种抗菌药物（青霉素、链霉素、土霉素、磺胺甲恶唑和庆大霉素）的敏感性。每种抗菌药物有3株耐药，14株对所检测的五种化合物中的三种或四种耐药，49株对单一药物或所选药物中的两种耐药。发现34株对所有检测的化合物均完全敏感。提示对庆大霉素和磺胺甲恶唑的耐药性可能由多重耐药基因决定。发现青霉素耐药的总体频率为26.5%（最低抑菌浓度大于0.06μg/ml），提示自1968年以来耐药性显著下降。
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本文引用的文献
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Br J Vener Dis. 1958 Jun;34(2):70-8; discussion 78-82. doi: 10.1136/sti.34.2.70.
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J Clin Pathol. 1970 Sep;23(6):481-3. doi: 10.1136/jcp.23.6.481.
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Br J Vener Dis. 1968 Dec;44(4):315-8. doi: 10.1136/sti.44.4.315.
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Acta Pathol Microbiol Scand B Microbiol Immunol. 1971;217:Suppl 217:1+.
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