Glisović L, Kilibarda V, Redzić B, Stanković N, Radulović S
Vojnomedicinska akademija, Odeljenje za toksikolosku hemiju, Klinika za gastroenterologiju.
Vojnosanit Pregl. 1993 Jul-Aug;50(4):365-9.
Concentrations of albendazole and its active metabolite in echinococcal cyst of the human liver were determined in order to evaluate drug effects of the decrease of protoscolex vitality. Albendazole concentration of 0-64.9 micrograms/ml and albendazole sulfoxide of 0-40.8 micrograms/ml were found in cysts. The protoscolexes showed markedly manifested morphologic changes up to the disintegration. The postoperative follow up of patients within 24 months discovered no recidives of the disease and the patients were regarded as cured. On the basis of the results obtained it has been concluded that the use of albendazole in the dose of 800 mg/day within 28 day is sufficient for achievement of therapeutic drug level in vivo conditions.
