O'Byrne E M, Paul P K, Roberts E D, Blancuzzi V, Wilson D, Goldberg R L, DiPasquale G
Research Department, Ciba-Geigy Corporation, Summit, NJ 07901.
Agents Actions. 1993;39 Spec No:C157-9. doi: 10.1007/BF01972752.
Osteoarthritis was surgically induced in mature male Dutch Belted rabbits by sectioning the fibular collateral and sesamoid ligaments and removal of the anterior horn of the lateral meniscus. The site of surgical intervention was detectable by MRI. Histopathologic analysis revealed severe focal cartilage lesions on opposing surfaces of the tibia and femur. Histology of cartilage adjacent to the osteoarthritic lesions appeared normal. In another animal model, arthritis was induced by immunization against ovalbumin followed by intra-articular injection of ovalbumin. MRI of immune arthritic rabbit knees showed accumulation of synovial fluid and cartilage degradation. Histopathology was characterized by vascular necrosis of the synovium and depletion of cartilage proteoglycan. MRI can be used to non-invasively follow the therapeutic effects of drug treatment on synovial inflammation and cartilage degradation in rabbit knees.
通过切断腓侧副韧带和籽骨韧带并切除外侧半月板前角，在成年雄性荷兰带兔身上手术诱导骨关节炎。手术干预部位可通过MRI检测到。组织病理学分析显示，胫骨和股骨相对表面出现严重的局灶性软骨损伤。骨关节炎病变相邻的软骨组织学表现正常。在另一种动物模型中，通过用卵清蛋白免疫，随后关节内注射卵清蛋白来诱导关节炎。免疫性关节炎兔膝关节的MRI显示滑液积聚和软骨降解。组织病理学特征为滑膜血管坏死和软骨蛋白聚糖耗竭。MRI可用于无创跟踪药物治疗对兔膝关节滑膜炎和软骨降解的治疗效果。
