Rainsford K D, Ying C, Smith F
Department of Biomedical Sciences, McMaster University Health Sciences Centre, Hamilton, Ontario, Canada.
Agents Actions. 1993;39 Spec No:C186-8. doi: 10.1007/BF01972761.
To determine the role of 5-LO regulation of IL-1 in synovial tissues, we examined the effects of 5-LO inhibitors compared with standard IL-1 synthesis inhibitors on IL-1 production by human synovial tissue explants from patients with inflammatory arthropathies. MK886, L-656,224, PF-5901, and tepoxalin all inhibited IL-1 production in concentrations up to 10 microM, whereas other 5-LO inhibitors (ICI-211,965, zileuton), as well as IL-1 synthesis inhibitors (IX-207,887, tenidap), were inactive. LT products, thus regulate IL-1 production and inhibition thereof is one strategy for inhibiting this cytokine.
为确定5-脂氧合酶（5-LO）对白细胞介素-1（IL-1）在滑膜组织中的调控作用，我们比较了5-LO抑制剂与标准IL-1合成抑制剂对炎性关节病患者人滑膜组织外植体产生IL-1的影响。MK886、L-656,224、PF-5901和替泊沙林在浓度高达10微摩尔时均抑制IL-1的产生，而其他5-LO抑制剂（ICI-211,965、齐留通）以及IL-1合成抑制剂（IX-207,887、替硝唑）均无活性。因此，白三烯产物调节IL-1的产生，抑制其产生是抑制这种细胞因子的一种策略。
