Panisset M, Roudier M, Saxton J, Boller F
McGill Center for Studies on Aging, St-Mary's Hospital, Montreal, Quebec.
Arch Neurol. 1994 Jan;51(1):41-5. doi: 10.1001/archneur.1994.00540130067012.
Patients with progressive dementia invariably evolve to a stage where they can no longer be tested by standard neuropsychological tests. We studied the use of the Severe Impairment Battery (SIB) in such patients.
Case series.
Geriatric long-term facility.
Sixty-nine patients who met the criteria of the Diagnostic and Statistical Manual for Mental Disorders, Revised Third Edition, for dementia were selected. The diagnosis of probable Alzheimer's disease was established according to the guidelines suggested by the National Institute of Neurologic and Communicative Diseases and Stroke/Alzheimer's Disease and Related Disorders Association. There were 18 men and 51 women. The mean age of the population was 82.99 +/- 5.66 years. The mean Mini-Mental State Examination (MMSE) score was 10.71 +/- 6.14.
To characterize the cognitive profile and evolution of severely demented patients by means of the SIB.
The mean score on the SIB was 92.52 +/- 31.92, with a possible maximum of 133 points. Subgroups of patients with the most severe degree of dementia (MMSE scores of 0 to 5 and 6 to 11) showed significant differences in their scores on the SIB. In contrast, no differences were found between subgroups with MMSE scores of 6 to 11, 12 to 17, and greater than 17. Fifteen patients who had MMSE scores of less than 6 had SIB scores ranging from 7 to 81. All cognitive domains showed a deterioration across the four severity groups as determined by the MMSE scores and also during a longitudinal study performed on 26 patients.
Our study indicates that the SIB is useful for the neuropsychological evaluation of severely demented patients and for their follow-up.
进行性痴呆患者最终会发展到无法通过标准神经心理学测试进行评估的阶段。我们研究了严重损伤成套测验（SIB）在这类患者中的应用。
病例系列研究。
老年长期护理机构。
选取了69名符合《精神障碍诊断与统计手册》第三版修订本中痴呆诊断标准的患者。根据美国国立神经疾病和中风研究所/阿尔茨海默病及相关疾病协会建议的指南确定可能的阿尔茨海默病诊断。其中男性18名，女性51名。患者平均年龄为82.99±5.66岁。简易精神状态检查表（MMSE）平均得分为10.71±6.14。
通过SIB来描述重度痴呆患者的认知特征和病情发展。
SIB平均得分为92.52±31.92，最高分为133分。痴呆程度最严重的患者亚组（MMSE评分为0至5分和6至11分）在SIB得分上存在显著差异。相比之下，MMSE评分为6至11分、12至17分和大于17分的亚组之间未发现差异。15名MMSE评分低于6分的患者SIB得分在7至81分之间。根据MMSE评分确定的四个严重程度组以及对26名患者进行的纵向研究均显示，所有认知领域均出现衰退。
我们的研究表明，SIB对重度痴呆患者的神经心理学评估及其随访有用。
