Draber S, Schultze R, Hansen U P
Institut für Angewandte Physik, Universität Kiel, Germany.
Biophys J. 1993 Oct;65(4):1553-9. doi: 10.1016/S0006-3495(93)81194-9.
Spontaneous cooperatively of K+ channels is studied in excised patches of Chara corallina tonoplasts. Bar histograms (dwell time versus number of open channels) are constructed from the time series of current by means of the higher-order Hinkley detector (R. Schultze and S. Draber. 1993. J. Membr. Biol. 132:41-52). A statistical test, based on these bar histograms, shows that the channels are not independent. Further analysis reveals that the channels are cooperatively changing their open probability, which leads to the idea of cooperative mode shifting.
在轮藻液泡膜的切除膜片中研究了钾离子通道的自发协同作用。通过高阶欣克利探测器(R.舒尔茨和S.德拉伯。1993年。《膜生物学杂志》132:41 - 52)根据电流时间序列构建柱状图(驻留时间与开放通道数量)。基于这些柱状图的统计检验表明,通道并非相互独立。进一步分析表明,通道正在协同改变其开放概率,这引出了协同模式转换的概念。