从受有限时间分辨率限制的数据中估计单通道动力学参数。
Estimation of single channel kinetic parameters from data subject to limited time resolution.
作者信息
Milne R K, Yeo G F, Madsen B W, Edeson R O
机构信息
Department of Mathematics, University of Western Australia, Nedlands.
出版信息
Biophys J. 1989 Apr;55(4):673-6. doi: 10.1016/S0006-3495(89)82865-6.
Abstract
The limited responsiveness of single-channel recording systems results in some brief events not being detected, and if this is ignored parameter estimation from the observed data will be biased. Statistical methods of correcting for this limited time resolution in a two-state Markov model have been proposed by Neher (1983. J. Physiol. (Lond.). 339:663-678) and by Colquhoun and Sigworth (1983. Single Channel Recording. 191-263). However, a numerical study by Blatz and Magleby (1986. Biophys. J. 49:967-980) indicated differences of 3-40% in the corrected values given by the two techniques. Here we explain why Neher's method produces biased results and the Colquhoun and Sigworth approach, which is no more difficult, provides reasonably accurate estimates.
摘要
单通道记录系统的响应能力有限，导致一些短暂事件无法被检测到，如果忽略这一点，从观测数据进行的参数估计将会有偏差。Neher（1983年，《生理学杂志》（伦敦）。339:663 - 678）以及Colquhoun和Sigworth（1983年，《单通道记录》。191 - 263）提出了在双态马尔可夫模型中校正这种有限时间分辨率的统计方法。然而，Blatz和Magleby（1986年，《生物物理学杂志》。49:967 - 980）的一项数值研究表明，这两种技术给出的校正值存在3% - 40%的差异。在此我们解释为什么Neher的方法会产生有偏差的结果，而Colquhoun和Sigworth的方法并不更难，却能提供合理准确的估计。
相似文献
1
Estimation of single channel kinetic parameters from data subject to limited time resolution.从受有限时间分辨率限制的数据中估计单通道动力学参数。
Biophys J. 1989 Apr;55(4):673-6. doi: 10.1016/S0006-3495(89)82865-6.
2
Yet another approach to the dwell-time omission problem of single-channel analysis.单通道分析中驻留时间遗漏问题的又一种解决方法。
Biophys J. 1990 Sep;58(3):731-43. doi: 10.1016/S0006-3495(90)82416-4.
3
Poisson sampling-based inference for single ion channel data with time interval omission.基于泊松抽样的单离子通道数据时间间隔省略推断
Proc Biol Sci. 1992 Dec 22;250(1329):263-9. doi: 10.1098/rspb.1992.0158.
4
Open channel noise. VI. Analysis of amplitude histograms to determine rapid kinetic parameters.开放通道噪声。VI. 用于确定快速动力学参数的幅度直方图分析
Biophys J. 1991 Sep;60(3):577-87. doi: 10.1016/S0006-3495(91)82087-2.
5
Data transformations for improved display and fitting of single-channel dwell time histograms.用于改善单通道驻留时间直方图显示和拟合的数据变换。
Biophys J. 1987 Dec;52(6):1047-54. doi: 10.1016/S0006-3495(87)83298-8.
6
Ion-channel gating mechanisms: model identification and parameter estimation from single channel recordings.离子通道门控机制：基于单通道记录的模型识别与参数估计
Proc R Soc Lond B Biol Sci. 1989 May 22;236(1285):385-416. doi: 10.1098/rspb.1989.0029.
7
Estimating kinetic parameters for single channels with simulation. A general method that resolves the missed event problem and accounts for noise.通过模拟估计单通道的动力学参数。一种解决漏事件问题并考虑噪声的通用方法。
Biophys J. 1990 Dec;58(6):1411-26. doi: 10.1016/S0006-3495(90)82487-5.
8
Adjustments for the display of quantized ion channel dwell times in histograms with logarithmic bins.用于在具有对数区间的直方图中显示量化离子通道驻留时间的调整。
Biophys J. 2000 Feb;78(2):662-7. doi: 10.1016/S0006-3495(00)76624-0.
9
Reaction kinetic parameters for ion transport from steady-state current-voltage curves.从稳态电流-电压曲线获取离子传输的反应动力学参数。
Biophys J. 1987 Apr;51(4):569-85. doi: 10.1016/S0006-3495(87)83382-9.
10
Correcting single channel data for missed events.针对漏检事件校正单通道数据。
Biophys J. 1986 May;49(5):967-80. doi: 10.1016/S0006-3495(86)83725-0.
引用本文的文献
1
Generalizing HMMs to Continuous Time for Fast Kinetics: Hidden Markov Jump Processes.将隐马尔可夫模型推广到连续时间以实现快速动力学：隐马尔可夫跳跃过程。
Biophys J. 2021 Feb 2;120(3):409-423. doi: 10.1016/j.bpj.2020.12.022. Epub 2021 Jan 7.
2
Hidden Markov analysis of improved bandwidth mechanosensitive ion channel data.改进带宽的机械敏感离子通道数据的隐马尔可夫分析
Eur Biophys J. 2015 Oct;44(7):545-56. doi: 10.1007/s00249-015-1060-7. Epub 2015 Aug 2.
3
Using a five-state model for fitting amplitude histograms from MaxiK channels: beta-distributions reveal more than expected.使用五态模型拟合MaxiK通道的幅度直方图：β分布揭示的信息超出预期。
Eur Biophys J. 2009 Oct;38(8):1101-14. doi: 10.1007/s00249-009-0515-0. Epub 2009 Jul 21.
4
Estimation of ion channel kinetics from fluctuations of macroscopic currents.根据宏观电流波动估算离子通道动力学
Biophys J. 2007 Jul 1;93(1):74-91. doi: 10.1529/biophysj.106.101212. Epub 2007 Apr 6.
5
Strengths and limits of Beta distributions as a means of reconstructing the true single-channel current in patch clamp time series with fast gating.作为一种在具有快速门控的膜片钳时间序列中重建真实单通道电流的方法，贝塔分布的优势与局限性
J Membr Biol. 2006 Apr;210(3):199-212. doi: 10.1007/s00232-006-0858-8. Epub 2006 Aug 14.
6
Rectifying conductance substates in a large conductance Ca(2+)-activated K+ channel: evidence for a fluctuating barrier mechanism.大电导钙激活钾通道中的整流电导亚态：波动屏障机制的证据
J Gen Physiol. 1996 Jan;107(1):47-68. doi: 10.1085/jgp.107.1.47.
7
Cooperative behavior of K+ channels in the tonoplast of Chara corallina.轮藻液泡膜中钾离子通道的协同行为。
Biophys J. 1993 Oct;65(4):1553-9. doi: 10.1016/S0006-3495(93)81194-9.
8
Fast single-channel measurements resolve the blocking effect of Cs+ on the K+ channel.快速单通道测量解析了Cs+对K+通道的阻断作用。
Biophys J. 1994 Jul;67(1):120-9. doi: 10.1016/S0006-3495(94)80461-8.
9
Single ion channel models incorporating aggregation and time interval omission.包含聚集和时间间隔省略的单离子通道模型。
Biophys J. 1993 Feb;64(2):357-74. doi: 10.1016/S0006-3495(93)81375-4.
10
Correction for missed events based on a realistic model of a detector.基于探测器实际模型对漏检事件进行校正。
Biophys J. 1994 Jan;66(1):191-201. doi: 10.1016/S0006-3495(94)80756-8.
本文引用的文献
1
Single-channel electrophysiology: use of the patch clamp.单通道电生理学：膜片钳技术的应用
Methods Enzymol. 1983;103:147-76. doi: 10.1016/s0076-6879(83)03011-6.
2
The charge carried by single-channel currents of rat cultured muscle cells in the presence of local anaesthetics.在局部麻醉剂存在的情况下，大鼠培养肌肉细胞单通道电流所携带的电荷。
J Physiol. 1983 Jun;339:663-78. doi: 10.1113/jphysiol.1983.sp014741.
3
Statistical inference from single channel records: two-state Markov model with limited time resolution.单通道记录的统计推断：具有有限时间分辨率的两态马尔可夫模型。
Proc R Soc Lond B Biol Sci. 1988 Oct 22;235(1278):63-94. doi: 10.1098/rspb.1988.0063.
4
Temporal clustering of ion channel openings incorporating time interval omission.结合时间间隔省略的离子通道开放的时间聚类
IMA J Math Appl Med Biol. 1987;4(4):333-61. doi: 10.1093/imammb/4.4.333.
5
Stochastic modelling of a single ion channel: an alternating renewal approach with application to limited time resolution.单离子通道的随机建模：一种交替更新方法及其在有限时间分辨率中的应用
Proc R Soc Lond B Biol Sci. 1988 Apr 22;233(1272):247-92. doi: 10.1098/rspb.1988.0022.
6
Data transformations for improved display and fitting of single-channel dwell time histograms.用于改善单通道驻留时间直方图显示和拟合的数据变换。
Biophys J. 1987 Dec;52(6):1047-54. doi: 10.1016/S0006-3495(87)83298-8.
7
Direct measurement of proton transfer rates to a group controlling the dihydropyridine-sensitive Ca2+ channel.
Nature. 1987;329(6136):243-6. doi: 10.1038/329243a0.
8
Correcting single channel data for missed events.针对漏检事件校正单通道数据。
Biophys J. 1986 May;49(5):967-80. doi: 10.1016/S0006-3495(86)83725-0.
9
Effect of limited interval resolution on single channel measurements with application to Ca channels.有限时间间隔分辨率对单通道测量的影响及其在钙通道中的应用
IEEE Trans Biomed Eng. 1985 Oct;32(10):786-97. doi: 10.1109/TBME.1985.325494.
10
A general solution to the time interval omission problem applied to single channel analysis.应用于单通道分析的时间间隔遗漏问题的通用解决方案。
Biophys J. 1985 Jul;48(1):149-58. doi: 10.1016/S0006-3495(85)83768-1.
Zotero 插件