Hawkins B R, Simons M J
Hum Hered. 1976;26(6):441-53. doi: 10.1159/000152839.
The distribution of the blood group systems ABO, Rhesus, MNSs and P was studied in all or some of 1,007 Singapore Chinese, ABO gene frequencies were found to be consistent with previous studies and did not vary significantly between dialects. An individual of phenotype A2B was detected although the population showed no other evidence for the A2 gene. The possible significance of this observation in terms of weak H alleles in the population is discussed. The frequencies of the MNSs genes are consistent with previous studies. Two subjects appeared to lack the NA component of the N antigen. The frequency of the R1 gene of the Rhesus system was lower than has been detected previously and may relate to dialect differences. No examples of the CW antigen were detected. The P blood group distribution appears to be subject to regional variation. It is concluded that classification of Chinese into dialect groups is a useful way of assessing genetic heterogeneity.
对1007名新加坡华人全部或部分样本的ABO、恒河猴、MNSs和P血型系统分布进行了研究。发现ABO基因频率与先前研究一致，且在不同方言群体间无显著差异。尽管该群体中没有其他A2基因的证据，但检测到一名A2B血型个体。讨论了这一观察结果在群体中弱H等位基因方面的可能意义。MNSs基因频率与先前研究一致。两名受试者似乎缺乏N抗原的NA成分。恒河猴系统中R1基因的频率低于先前检测到的频率，可能与方言差异有关。未检测到CW抗原的实例。P血型分布似乎存在区域差异。得出结论，将华人按方言群体分类是评估遗传异质性的一种有用方法。
