Osmond C, Barker D J, Winter P D, Fall C H, Simmonds S J
MRC Environmental Epidemiology Unit, University of Southampton, Southampton General Hospital.
BMJ. 1993 Dec 11;307(6918):1519-24. doi: 10.1136/bmj.307.6918.1519.
To determine whether the link suggested between growth in utero and during infancy and death from cardiovascular disease in men is also present in women.
Follow up study of women and men whose birth weight and weight at 1 year of age had been recorded.
Hertfordshire, England.
5585 women and 10,141 men born during 1911-30.
Standardised mortality ratios for cardiovascular disease.
Among women and men death rates from cardiovascular disease fell progressively between the low and high birth weights groups (chi 2 = 4.3, p = 0.04 for women, chi 2 = 8.5, p < 0.005 for men). Cardiovascular deaths in men but not women were also strongly related to weight at 1 year, falling progressively between the low and high weight groups (chi 2 = 27.5, p < 0.0001). The highest cardiovascular death rates in women were among those with below average birth weight but above average weight at 1 year. In men the highest rates were among those with below average birth weight and below average weight at 1 year.
Relations between cardiovascular disease and birth weight are similar in men and women. In men cardiovascular disease is also related to weight gain in infancy.
确定子宫内及婴儿期生长与男性心血管疾病死亡之间的关联在女性中是否也存在。
对出生体重和1岁时体重有记录的男性和女性进行随访研究。
英国赫特福德郡。
1911年至1930年间出生的5585名女性和10141名男性。
心血管疾病的标准化死亡率。
在女性和男性中，心血管疾病死亡率在低出生体重组和高出生体重组之间逐渐下降（女性：χ² = 4.3，p = 0.04；男性：χ² = 8.5，p < 0.005）。男性的心血管疾病死亡与1岁时的体重也密切相关，在低体重组和高体重组之间逐渐下降（χ² = 27.5，p < 0.0001）。女性中心血管疾病死亡率最高的是那些出生体重低于平均水平但1岁时体重高于平均水平的人。男性中死亡率最高的是那些出生体重低于平均水平且1岁时体重低于平均水平的人。
心血管疾病与出生体重之间的关系在男性和女性中相似。在男性中，心血管疾病也与婴儿期体重增加有关。
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